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Hello, I have been on hydrocodone/apap for going on four years now.  I take 750 mgs up to four times a day for fibromyalgia, arthritis, and the remnants of a knee injury from being hit by a car.  I recently asked my doc, who I love for finally giving me seious pain meds after years of me living on huge doses of ibuprophen, about upping my dosage.  She reminded me that, while she would if I needed it, that I was going to be on the stuff for a long time, ie. life, and that each time I up the dosage I will be coming closer to the range of too much.  I guess what I mean is that you can be on this stuff for years, but that you must really think about your usage.  I will never want to be without some type of opiate, not because of addiction, but because the quality of my life is so much better now.  I can face the day knowing that there will be times without the debilitating aches and I will be able to function as a mom and wife, and member of the human race.  I went for years, in pain, real pain, unable to function almost at all.  If I forced myself, I paid the price.  I now have a life, not as active as I'd like maybe, but a whole lot better than before the meds.  I hope this helps you with your question.  Peace, Susan