The CDC released the findings of their new study published last week in The American Journal of Obstetrics and Gynecology indicating that taking opioid painkillers such as codeine, hydrocodone or oxycodone shortly before or during early pregnancy may increase the risk of birth defects. If you find yourself in this situation, please don't panic. Although the headline is technically true, the risk is still very low. Please read the rest of this post to learn more about what this study found. Study Design and Results The purpose of the study was to see if treatment with any opioid analgesic medication just before or during early pregnancy was associated with the occurrence of certain birth defects. The study used data from the National Birth Defects Prevention Study , a population-based, case-control study to understand the causes of and risk factors for major birth defects in the United States. Researchers found that 2%-3% of the mothers interviewed were treated wi...
It's not unusual for people living with chronic pain to also be dealing with some depression and/or anxiety . But if you're taking an opioid like oxycodone for the pain and also taking an herbal supplement containing St. John's Wort, you may unknowingly be reducing the effectiveness of your pain medication. A small study in Finland found that when St. John's Wort and oxycodone were taken together, the plasma concentration of oxycodone decreased by 50 percent and its half-life (the time it takes for half the drug to be elimitated from the body) was shortened by 27 percent. The reason for the significant decrease in oxycodone's effectiveness may lie in the fact that St. John’s wort is a well-known to induce CYP450 liver enzymes, which play an important role in the metabolism of many opioids. Although oxycodone was the only opioid tested, it would be logical to think that other opioids which are metabolized through the CYP450 pathways might be similarly...
I took a oxycodone 5mg and 15 min later was given a toradol shot. Is this safe? Amy.
There are no significant interactions between these two medications to make the combination unsafe.
That said, it doesn't mean they're safe for you. It depends on more than those two medications. It also depends on all other medications you're taking and any medical issues you may have. Hopefully, you remembered to tell the doctor who ordered the Toradol about the oxycodone, and he or she considered that before ordering the Toradol.
Good luck, John Claude Krusz and Teri Robert
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