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Alternative Names Overdose - hydrocodone; Overdose - oxycodone; Vicodin overdose; Percocet overdose; Percodan overdose; MSContin overdose; OxyContin overdose References Goldfrank LR, Flomenbaum NE, Lewin NA, et al. Goldfrank's Toxicologic Emergencies . 8th ed. New York, NY: McGraw-Hill; 2006.
You've probably been hearing in the news that an FDA advisory panel has recommended lowering the maximum recommended dose of acetaminophen from 1,000 mg per dose to 650 mg. They also recommended lowering the maximum daily dose, which is currently 4 grams (4,000 mg). Although they didn't specify what the maximum daily dose should be lowered to, it would most likely be in the neighborhood of 2,600 mg per day. The reason the FDA is considering changing their recommendations is that acetaminophen overdose is currently the leading cause of liver failure in the U.S. What many news reports are not telling you, though, is that this same advisory panel, by a narrow margin, also recommended banning hydrocodone and oxycodone products like Vicodin and Percocet that contain acetaminophen. (Vicodin and its generic counterparts contain hydrocodone and acetaminophen. Percocet and its generic formulations contain oxycodone and acetaminophen.) According to a 2005 stu...
Qualitest, a subsidiary of Endo Health Solutions, has issued a voluntary nationwide recall for 101 lots of Hydrocodone Bitartrate and Acetaminophen Tablets , USP 10 mg/500 mg. Bottles from the affected lots may contain tablets that have a higher dosage of acetaminophen, and as a result, it is possible that consumers could take more than the intended acetaminophen dose.
The problem with getting too much acetaminophen is that it could result in liver toxicity, especially in patients on other acetaminophen containing medications, patients with liver dysfunction, or people who consume more than three alcoholic beverages a day.
The affected lots, were distributed between Feb. 20, 2012 and Nov. 19, 2012 to wholesale distributors and retail pharmacies nationwide. For a list of the lot numbers, see Qualitest's press release .
If you have hydrocodone/acetaminophen tablets from the affected lots, contact Qualitest at 1-800-444-4011. If you are unsure if you have the affected ...
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