It's not unusual for people living with chronic pain to also be dealing with some depression and/or anxiety . But if you're taking an opioid like oxycodone for the pain and also taking an herbal supplement containing St. John's Wort, you may unknowingly be reducing the effectiveness of your pain medication. A small study in Finland found that when St. John's Wort and oxycodone were taken together, the plasma concentration of oxycodone decreased by 50 percent and its half-life (the time it takes for half the drug to be elimitated from the body) was shortened by 27 percent. The reason for the significant decrease in oxycodone's effectiveness may lie in the fact that St. John’s wort is a well-known to induce CYP450 liver enzymes, which play an important role in the metabolism of many opioids. Although oxycodone was the only opioid tested, it would be logical to think that other opioids which are metabolized through the CYP450 pathways might be similarly...
Yesterday Pfizer, Inc. and Acura Pharmaceuticals, Inc. announced they had received marketing approval from the FDA for Oxecta, a new abuse-resistant formulation of immediate-release oxycodone. Oxycodone is an opioid analgesic used for the management of both acute and chronic moderate to severe pain. Oxecta is the first immediate-release oxycodone medicine that applies technology designed to discourage common methods of tampering associated with opioid abuse and misuse. This technology, known as Aversion® Technology , uses a unique composition of commonly used pharmaceutical ingredients that prevent the medicine from being dissolved or crushed for the purpose of abusing them. Pfizer is licensing the technology in Oxecta from Acura. In their press release, the companies noted, “Opioid medications are an important treatment option for patients with moderate to severe pain who are not adequately managed by other pain treatments. However, abuse and misuse o...
Generic Name: OXYCODONE CONCENTRATE SOLUTION - ORAL Pronounced: (OX-i-KOE-done) Oxycodone Oral Uses
This medication is used to help relieve moderate to severe
pain. Oxycodone belongs to a class of drugs known as narcotic (opiate)
analgesics. It works in the brain to change how your body feels and responds to
How To Use Oxycodone Oral
Take this medication by mouth as directed by your doctor.
You may take this drug with or without food. If you have nausea, it may help to
take this drug with food. Ask your doctor or pharmacist about other ways to
decrease nausea (such as lying down for 1 to 2 hours with as little head
movement as possible).
Use the provided medicine dropper to carefully measure the
dose. Do not use a household spoon because you may not get the correct dose. Do
not confuse the dose in milligrams (mg) with the dose in milliliters (mL). You
may mix the dose with a small amount of juice, water, applesauce or pudding.
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