Definition Charcot-Marie-Tooth disease is a group of inherited disorders that affect the peripheral nerves (those outside the brain and spine). Alternative Names Progressive neuropathic (peroneal) muscular atrophy; Hereditary peroneal nerve dysfunction; Neuropathy - peroneal (hereditary); Hereditary motor and sensory neuropathy Causes, incidence, and risk factors Charcot-Marie-Tooth is one of the most common inherited nerve-related disorders. Defects in at least 14 genes cause different forms of this disease. The disease involves damage to the covering ( myelin sheath) around nerve fibers. In some, the disease causes destruction of the myelin sheath. In others, the central (axon) portion of the nerve cell wears away. Nerves that stimulate movement (the motor nerves) are most severely affected. The nerves in the legs are affected first and most severely.
Can Migraine be hereditary? Elaine.
Yes, it has been shown that Migraine is a genetic neurological disease. When trying to trace it back through families, you should also ask about "sick headaches" because Migraines were often called "sick headaches" in previous generations. Also ask abut sinus headaches because many people mistake Migraines for sinus headaches.
When one parent has Migraine in their family history, there's a 50% chance that children will inherit the disease. That jumps to 75% if there's Migraine in the family history of both parents.
Here's some information for you:
Sinuses Giving You a Headache? It’s Probably a Migraine
Gene Linked To Migraine and Increased Stroke Risk
Hemiplegic Migraine - Genetic Testing May Be Helpful
Thanks for your question, John Claude Krusz and Teri Robert
About Ask the Clinician :
Dr. Krusz is a recognized expert in the fields of headache...
Hereditary lymphedema is an inherited lymph system disorder. It is characterized by swelling of subcutaneous tissue caused by obstruction of lymphatic vessels and resulting edema of lymph fluid. There are three forms of hereditary lymphedema: 1. congenital (Milroy disease; Nonne-Milroy-Meige syndrome 2. lymphedema praecox (Meige disease) 3. lymphedema tarda Familial forms of congenital lymphedema (Milroy's disease) and lymphedema praecox (Meige's disease) may be inherited in an autosomal dominant manner with variable penetrance; autosomal or sex-linked recessive forms are less common. Related abnormalities can also occur, such as distichiasis, extradural cysts, vertebral abnormalities, cerebrovascular malformation, pleural effusion , cleft palate, hearing loss , and yellowing of the nails. Women are affected more frequently than men. This disease is genetically determined. Lymphedema is generally a painless condition, but patients may experience a chronic , dull, heavy sensation in the ...
You should knowAnswers to your question are meant to provide general health information but should not replace medical advice you receive from a doctor. No answers should be viewed as a diagnosis or recommended treatment for a condition. Content posted by community members does not necessarily reflect the views of Remedy Health Media, which also reserves the right to remove material deemed inappropriate.