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They are very similar drugs-  In fact, if you go to to most pharmacies with a prescription for either, and you ask for generic, you may get the same thing as replacement.  Also, the triplicate prescription one needs for percocet is not needed with vocodin.  But, I may be off here with one thing-  Is percocet compounded with aspirin?  I know that Vicodin is hydrocoone with Tylenol and can''t remember if the percoocet has asa or acet.. or if it's percodan that is compounded with asa or Acet.. hmm;  ask him or her!   This answer is incorrect.  Please see my answer below. – Karen Lee Richards, ChronicPainConnection Expert