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Earlier this month, the FDA's Anesthetic and Analgesic Drug Products Advisory Committee overwhelmingly voted against recommending approval of Zohydro ER, an extended-release version of hydrocodone. If approved, Zohydro ER would have been the first hydrocodone medication available that did not also contain a non-opioid analgesic such as acetaminophen or ibuprofen.
While the FDA does not have to follow the recommendation of its advisory committee, it usually does. The final determination is expected to be made by March 1, 2013.
Despite the fact that Zohydro ER was studied in nearly 1,500 patients––some for as long as a year––and found to be generally safe and well-tolerated with no new or unexpected safety problems, panel members expressed concerns with potential abuse, addiction and long-term safety.
It was noted that the manufacturer didn't offer any solution as to how they would limit unintended use other than the already tight distributio...
Ladies and gentlemen, welcome to the Heavyweight Pain Reliever Championship Match. In the blue corner, weighing in at 200 mg's is the most common NSAID (non-steroidal anti-inflammatory) found anywhere, ibuprofen . In the red corner, weighing in at a small, but mighty, 10 mg's is the most popular, most commonly prescribed opioid, hydrocodone . Today's match promises to be a real bell ringer. Who is the fastest? Who lasts the longest? Who can go the distance? Who packs the biggest punch? This decisive match will determine whether or not NSAID's or Opioids are the best pain relievers on the planet.
ROUND 1: Both the NSAID and the Opioid are off to a fast and furious pace; their analgesic onset is roughly equivalent in speed. Within the half hour, both have started to provide pain relief. At just a little over one hour, both appear to be at full strength and hitting equally hard. This fight should be one for the record books folks. Ding. Ding.
ROUND 2: With round 1 being...
Definition Hydrocodone and acetaminophen overdose occurs when someone accidentally or intentionally takes more than the normal or recommended amount of a painkiller containing both the opioid medication, hydrocodone, and acetaminophen (Tylenol). This is for information only and not for use in the treatment or management of an actual poison exposure. If you have an exposure, you should call your local emergency number (such as 911) or the National Poison Control Center at 1-800-222-1222. Alternative Names Lorcet overdose; Lortab overdose Poisonous Ingredient Acetaminophen (Tylenol) Hydrocodone (narcotic) Where Found Acetaminophen with hydrocodone is the main ingredient in many prescription painkillers, including: Anexsia Anolor DH Lortab Lorcet Norco Vicodin Zydone Note: This list may not include all sources of hydrocodone and acetaminophen.
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