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Last week, the United States Food and Drug Administration (FDA) made it official: Lyrica, the trade name of the Pfizer drug pregabalin, was approved as a treatment for fibromyalgia . This is the first drug to be specifically approved for the treatment of fibromyalgia, this based on the findings that it reduced pain and improved the ability to perform the activities of daily living in a significant number of patients suffering from this chronic pain syndrome. However, an FDA official cautioned that not all patients experienced benefit from Lyrica. Lyrica was already approved for the treatment of other chronic pain disorders , including pain associated with shingles and diabetic neuropathy. This additional approval was based upon two large studies which concluded that benefit could be had with daily dosages of Lyrica in the 300 mg to 450 mg range. The use of Lyrica resulted in an increased time to loss of therapeutic response compared to placebo over a six month p...
A case was recently reported of a 70-year-old man who developed rhabdomyolysis after his Lyrica (pregabalin) dosage was increased and he was also given Zocor (simvastatin), a statin drug usually given for high cholesterol. Rhabdomyolysis is the breakdown of muscle fibers that leads to the release of muscle fiber contents (myoglobin) into the bloodstream, which is harmful to the kidneys and often causes kidney damage.
When he arrived at the emergency room, the man was mentally disoriented, he was unable to stand up, all four extremities were twitching and he had slurred speech. Other symptoms of rhabdomyolysis may include:
Dark, red or cola colored urine
Decreased urine production
Muscle stiffness or aching
Weakness of affected muscles
Unintentional weight gain
Statin drugs are known to sometimes cause rhabdomyolysis. Lyrica is not generally recognized as a cause of rhabdomyolysis, although in t...
Puffy face; Swelling of the face; Moon face; Facial edema
Apply cold compresses to reduce swelling from an injury. Raise the head of the bed (or use extra pillows) to help reduce facial swelling.
Call your health care provider if
You should call your health care provider if you have:
Sudden, painful, or severe facial swelling
Facial swelling that lasts a while, particularly if it is getting worse over time
Fever, tenderness, or redness, which suggests infection
What to expect at your health care provider's office
Emergency treatment is needed if facial swelling is caused by burns or if you have breathing problems.
The health care team will ask questions about your medical and personal history to determine treatment or if any medical tests are needed. Questions may include:
How long has the facial swelling lasted?
When did it begin?
What makes it worse?
You should know
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