Last week, the United States Food and Drug Administration (FDA) made it official: Lyrica, the trade name of the Pfizer drug pregabalin, was approved as a treatment for fibromyalgia . This is the first drug to be specifically approved for the treatment of fibromyalgia, this based on the findings that it reduced pain and improved the ability to perform the activities of daily living in a significant number of patients suffering from this chronic pain syndrome. However, an FDA official cautioned that not all patients experienced benefit from Lyrica. Lyrica was already approved for the treatment of other chronic pain disorders , including pain associated with shingles and diabetic neuropathy. This additional approval was based upon two large studies which concluded that benefit could be had with daily dosages of Lyrica in the 300 mg to 450 mg range. The use of Lyrica resulted in an increased time to loss of therapeutic response compared to placebo over a six month p...
As of this writing, three medications have been approved by the FDA for the treatment of fibromyalgia: Lyrica (pregabalin), Cymbalta (duloxetine) and Savella (milnacipran). Since all three are relatively new drugs, information on how well they work and their side effects is still being gathered. Because every patient's symptoms and body chemistry are different, it is often a matter of trial and error to find the best medication for a particular patient with a particular illness. However, a recent German study , which was the first to compare the pros and cons of the three drugs head-to-head, may help doctors choose which medication has the best chance of success for any given patient. Study Design The study authors searched MEDLINE, SCOPUS, Cochrane Central Register of Controlled Trials, and sought unpublished data from the databases of FDA, US National Institutes for Health, and Industry through May 2009 for randomized controlled trials. They found 17...
Puffy face; Swelling of the face; Moon face; Facial edema
Apply cold compresses to reduce swelling from an injury. Raise the head of the bed (or use extra pillows) to help reduce facial swelling.
Call your health care provider if
You should call your health care provider if you have:
Sudden, painful, or severe facial swelling
Facial swelling that lasts a while, particularly if it is getting worse over time
Fever, tenderness, or redness, which suggests infection
What to expect at your health care provider's office
Emergency treatment is needed if facial swelling is caused by burns or if you have breathing problems.
The health care team will ask questions about your medical and personal history to determine treatment or if any medical tests are needed. Questions may include:
How long has the facial swelling lasted?
When did it begin?
What makes it worse?
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