Wednesday, October 01, 2014

Monday, June 09, 2008 William Gager, Community Member, asks

Q: how long does it take percocets to leave your system so it does not show up on a urine test

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Answers (2)
Karen Lee Richards, Health Guide
10/ 6/08 3:06pm

If you are taking a drug that has been prescribed for you, all you have to do is take your prescription with you to the drug test and there should be no problem.  If you are taking drugs other than those prescribed for you, the best thing we can do for you is encourage you to get any help you need to stop taking them as soon as possible.  For information and help, call The National Alcohol and Substance Abuse Information Center hotline at 1-800-784-6776 in the U.S. and 1-215-784-1120 outside the U.S. or visit the NASAIC site at:  http://www.addictioncareoptions.com/

For more information about employment-related drug screenings, read: "Passing" Those Drug Screenings."

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wesselj, Community Member
10/ 6/08 12:11pm

This information is from rxlist.com:Metabolism and Elimination

 

A high portion of oxycodone is N-dealkylated to noroxycodone during first-pass metabolism. Oxymorphone, is formed by the O-demethylation of oxycodone. The metabolism of oxycodone to oxymorphone is catalyzed by CYP2D6. Free and conjugated noroxycodone, free and conjugated oxycodone, and oxymorphone are excreted in human urine following a single oral dose of oxycodone. Approximately 8% to 14% of the dose is excreted as free oxycodone over 24 hours after administration. Following a single, oral dose of oxycodone, the mean ± SD elimination half-life is 3.51 ± 1.43 hours.

Acetaminophen is metabolized in the liver via cytochrome P450 microsomal enzyme. About 80-85% of the acetaminophen in the body is conjugated principally with glucuronic acid and to a lesser extent with sulfuric acid and cysteine. After hepatic conjugation, 90 to 100% of the drug is recovered in the urine with in the first day.

About 4% of acetaminophen is metabolized via cytochrome P450 oxidase to a toxic metabolite which is further detoxified by conjugation with glutathione, present in a fixed amount. It is believed that the toxic metabolite NAPQI (N acetyl-p-benzoquinoneimine, N-acetylimidoquinone) is responsible for liver necrosis. High doses of acetaminophen may deplete the glutathione stores so that inactivation of the toxic metabolite is decreased. At high doses, the capacity of metabolic pathways for conjugation with glucuronic acid and sulfuric acid may be exceeded, resulting in increased metabolism of acetaminophen by alternate pathways.

 

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tasteen2000, Community Member
9/10/09 3:43am

2 or 3 days.

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Mrsdualcitz, Community Member
8/ 8/12 12:09pm
Why are people worried if it shows up in a urine test? If you are taking it on the advice of a MD,there Is nothing to be ashamed about???:) I take as needed when back ( 2 herniated disks) is really ,really bad. I have gone down to a smaller dose ( at MY request) of OxyContin from 100 mg a day a year ago,to 20 mg in the morning,to 15 mg at night. I do not want to have surgery yet.when my back goes out( electricity all over,numbness,and extreme pain,I have my emergency stash of Percocet ,that I used to take daily. I also have panic attacks,that are well controlled with klonopin.Sorry to be off subject! Chronic pain and panic attacks ,still seem to be such a " stigma" in our society. Have a good day everybody. Reply
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By William Gager, Community Member— Last Modified: 08/08/12, First Published: 06/09/08