• wesselj October 06, 2008
    October 06, 2008

    This information is from and Elimination


    A high portion of oxycodone is N-dealkylated to noroxycodone during first-pass metabolism. Oxymorphone, is formed by the O-demethylation of oxycodone. The metabolism of oxycodone to oxymorphone is catalyzed by CYP2D6. Free and conjugated noroxycodone, free and conjugated oxycodone, and oxymorphone are excreted in human urine following a single oral dose of oxycodone. Approximately 8% to 14% of the dose is excreted as free oxycodone over 24 hours after administration. Following a single, oral dose of oxycodone, the mean ± SD elimination half-life is 3.51 ± 1.43 hours.

    Acetaminophen is metabolized in the liver via cytochrome P450 microsomal enzyme. About 80-85% of the acetaminophen in the body is conjugated principally with glucuronic acid and to a lesser extent with sulfuric acid and cysteine. After hepatic conjugation, 90 to 100% of the drug is recovered in the urine with in the first day.

    About 4% of acetaminophen is metabolized via cytochrome P450 oxidase to a toxic metabolite which is further detoxified by conjugation with glutathione, present in a fixed amount. It is believed that the toxic metabolite NAPQI (N acetyl-p-benzoquinoneimine, N-acetylimidoquinone) is responsible for liver necrosis. High doses of acetaminophen may deplete the glutathione stores so that inactivation of the toxic metabolite is decreased. At high doses, the capacity of metabolic pathways for conjugation with glucuronic acid and sulfuric acid may be exceeded, resulting in increased metabolism of acetaminophen by alternate pathways.


    • tasteen2000
      September 10, 2009
      September 10, 2009

      2 or 3 days.

    • Mrsdualcitz
      August 08, 2012
      August 08, 2012
      Why are people worried if it shows up in a urine test? If you are taking it on the advice of a MD,there Is nothing to be ashamed about???:) I take as needed when back ( 2 herniated disks) is really ,really bad. I have gone down to a smaller dose ( at MY request) of OxyContin from 100 mg a day a year ago,to 20 mg in the morning,to 15 mg at night. I do not want to have surgery yet.when my back goes out( electricity all over,numbness,and extreme pain,I have my emergency stash of Percocet ,that I used to take daily. I also have panic attacks,that are well controlled with klonopin.Sorry to be off subject! Chronic pain and panic attacks ,still seem to be such a " stigma" in our society. Have a good day everybody. READ MORE
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