FROM OUR EXPERTS
Generic Name: IBUPROFEN/OXYCODONE 400 MG/5 MG - ORAL Pronounced: (eye-byou-PRO-fen/ox-ee-KOH-doan) Ibuprofen-Oxycodone Oral Interactions
Drug interactions may change how your medications work or
increase your risk for serious side effects. This document does not contain all
possible drug interactions. Keep a list of all the products you use (including
prescription/nonprescription drugs and herbal products) and share it with your
doctor and pharmacist. Do not start, stop, or change the dosage of any
medicines without your doctor's approval.
Some of the products that may interact with this drug
certain antidepressants (SSRIs such as fluoxetine/sertraline,
SNRIs such as duloxetine)
anti-platelet drugs (such as clopidogrel,
bisphosphonates taken by mouth (such as
"blood thinners" (such as dabigatran, enoxaparin, heparin,
certain cancer drugs (mercaptopurine, methotrexate,
Yesterday the U.S. Food and Drug Administration announced that it is asking manufacturers of prescription combination products that contain acetaminophen to limit the amount of acetaminophen to no more than 325 mg (milligrams) in each tablet or capsule. Acetaminophen is probably best known by the brand name Tylenol. Outside the U.S., it is often called paracetamol and on prescriptions it may be labeled as APAP (For example, hydrocodone APAP). The drugs most affected by this action are opioid pain relievers that are combined with acetaminophen like codeine (Tylenol #3), hydrocodone (Vicodin, Lortab) and oxycodone (Percocet). “FDA is taking this action to make prescription combination pain medications containing acetaminophen safer for patients to use,” said Sandra Kweder, M.D., deputy director of the Office of New Drugs in FDA’s Center for Drug Evaluation and Research (CDER). “Overdose from prescription combination products containing acetaminop...
My daughter who is 15 has been suffering from daily migraines since March 2008. She sees a neurologist. They first put her on Topomax-nothing changed. She has now been on HYDROCO/APAP for a month and still has excruciating pain daily. What should we do next? Her grades are suffering and she does not sleep well either. Maureen .
There are several issues here.
The hydrocodone and acetaminophen may well be making matters worse by causing medication overuse headaches (MOH), aka rebound. Pain medications need to be limited to two or three days a week to avoid MOH. For more information on this, please see Medication Overuse Headache - When the Remedy Backfires . Another problem MOH can cause it that it can keep Migraine preventive medications from working.
How long did she try the Topamax? It can take up to three months to know if that type of medication is going to w...
You should know
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