Researchers at the Fisher Center for Alzheimer’s Disease Research at The Rockefeller University have published the results of their recent study, which showed that non-steroidal anti-inflammatory drugs (NSAIDs) reduced the effectiveness of selective serotonin reuptake inhibitor (SSRI) antidepressants.
NSAIDs include over-the-counter medications like ibuprofen, aspirin and naproxen as well as prescriptions drugs such as Celebrex, Daypro, diclofenac, etodolac, ketoprofen, meloxicam, Mobic, Naprosyn, Relafen, Toradol, Voltaren, etc.
You may be wondering what this study has to do with chronic pain. Antidepressants are sometimes prescribed as a treatment for chronic pain because they help increase serotonin, which is important for pain modulation. If NSAIDs prevent antidepressants from being effective for depression, they may also interfere with the ability of antidepressants to reduce pain. Study Design and Results Scientists first tested their theory on mice...
Long term use of the painkiller ibuprofen when taken for more than five years has been found to decrease the risk of Alzheimer's disease by 40 percent. Published in the
Journal of Neurology, this large scale study demonstrated that the type of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) was important in risk reduction. They found some NSAIDs less effective than others. Indomethacine only reduced risk of Alzheimer's by 25 pecent and Pfizer's Celebrex and Celecox had no effect at all.
The newly published study looks at work carried out by researchers from Boston University School of Medicine, Boston University School of Public Health and Bedford Veterans Affairs Medical center. It involved over 49,000 veterans aged 55 years and older.
The ibuprofen group of medicines include brand names such as Advil, Motrin and Nurofen. NSAIDs are one of the most widely used drugs for pain relief of non-serious arthritic conditions, for rheumatic or muscular pain, backache...
Although triptans are a marked improvement over previous treatment options, many Migraineurs have not been fully satisfied with their results. Some do not achieve full relief from triptans, and the recurrence of Migraines within 24 hours of the first dose has been common. With the patents on sumatriptan nearing their expiration, both generics of the current forms – injections, tablets, and nasal spray – and other medications containing sumatriptan are now in development and testing. The results involving Trexima, one such medication that is a combination of sumatriptan and naproxen, have now been published. Read Study Finds Sumatriptan-Naproxen Combination More Effective against Migraine Attacks .
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