Researchers at the Fisher Center for Alzheimer’s Disease Research at The Rockefeller University have published the results of their recent study, which showed that non-steroidal anti-inflammatory drugs (NSAIDs) reduced the effectiveness of selective serotonin reuptake inhibitor (SSRI) antidepressants.
NSAIDs include over-the-counter medications like ibuprofen, aspirin and naproxen as well as prescriptions drugs such as Celebrex, Daypro, diclofenac, etodolac, ketoprofen, meloxicam, Mobic, Naprosyn, Relafen, Toradol, Voltaren, etc.
You may be wondering what this study has to do with chronic pain. Antidepressants are sometimes prescribed as a treatment for chronic pain because they help increase serotonin, which is important for pain modulation. If NSAIDs prevent antidepressants from being effective for depression, they may also interfere with the ability of antidepressants to reduce pain. Study Design and Results Scientists first tested their theory on mice...
Generic Name: NAPROXEN/ESOMEPRAZOLE - ORAL Pronounced: (na-PROX-en/ES-oh-MEP-ra-zole) Naproxen-Esomeprazole Oral Precautions
Before taking naproxen/esomeprazole, tell your doctor or
pharmacist if you are allergic to either of them; or to aspirin or other NSAIDs
(such as ibuprofen, celecoxib); or to other proton-pump inhibitors such as
omeprazole, pantoprazole; or if you have any other allergies. This product may
contain inactive ingredients, which can cause allergic reactions or other
problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or
pharmacist your medical history, especially of:
aspirin-sensitive asthma (a history of worsening breathing
with runny/stuffy nose after taking aspirin or other NSAIDs)
stomach/intestinal/esophagus problems (such as bleeding,
ulcers, recurring heartburn)
heart disease (such as congestive heart failure, history of
Although triptans are a marked improvement over previous treatment options, many Migraineurs have not been fully satisfied with their results. Some do not achieve full relief from triptans, and the recurrence of Migraines within 24 hours of the first dose has been common. With the patents on sumatriptan nearing their expiration, both generics of the current forms – injections, tablets, and nasal spray – and other medications containing sumatriptan are now in development and testing. The results involving Trexima, one such medication that is a combination of sumatriptan and naproxen, have now been published. Read Study Finds Sumatriptan-Naproxen Combination More Effective against Migraine Attacks .
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