Generic Name: OXYCODONE CONCENTRATE SOLUTION - ORAL Pronounced: (OX-i-KOE-done) Oxycodone Oral Interactions
The effects of some drugs can change if you take other
drugs or herbal products at the same time. This can increase your risk for
serious side effects or may cause your medications not to work correctly. These
drug interactions are possible, but do not always occur. Your doctor or
pharmacist can often prevent or manage interactions by changing how you use
your medications or by close monitoring.
To help your doctor and pharmacist give you the best care,
be sure to tell your doctor and pharmacist about all the products you use
(including prescription drugs, nonprescription drugs, and herbal products)
before starting treatment with this product. While using this product, do not
start, stop, or change the dosage of any other medicines you are using without
your doctor's approval.
Some products that may interact with this drug
Generic Name: OXYCODONE/ASPIRIN - ORAL Pronounced: (ox-ee-KOH-doan/AS-pir-in) Oxycodone-Aspirin Oral Precautions
Before taking oxycodone with aspirin, tell your doctor or
pharmacist if you are allergic to it; or to other narcotics (such as codeine,
hydrocodone), salicylates (such as salsalate), or nonsteroidal
anti-inflammatory drugs (such as ibuprofen, naproxen, celecoxib); or if you
have any other allergies. This product may contain inactive ingredients, which
can cause allergic reactions or other problems. Talk to your pharmacist for
Before using this medication, tell your doctor or
pharmacist your medical history, especially of:
intestinal/bowel disorders (such as paralytic ileus,
infectious diarrhea, colitis, blockage)
bleeding/blood-clotting disorders (such as hemophilia,
vitamin K deficiency, low platelet count)
stomach problems (such as ulcers, heartburn, stomach
It's not unusual for people living with chronic pain to also be dealing with some depression and/or anxiety . But if you're taking an opioid like oxycodone for the pain and also taking an herbal supplement containing St. John's Wort, you may unknowingly be reducing the effectiveness of your pain medication. A small study in Finland found that when St. John's Wort and oxycodone were taken together, the plasma concentration of oxycodone decreased by 50 percent and its half-life (the time it takes for half the drug to be elimitated from the body) was shortened by 27 percent. The reason for the significant decrease in oxycodone's effectiveness may lie in the fact that St. John’s wort is a well-known to induce CYP450 liver enzymes, which play an important role in the metabolism of many opioids. Although oxycodone was the only opioid tested, it would be logical to think that other opioids which are metabolized through the CYP450 pathways might be similarly...
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