Saturday, February 21, 2009 janeles50, Community Member, asks

Q: 5-HTP/SAMe-can I take both of these?

I have fibromyalgia. I started taking 5-HTP on 1/31/09. It has made a significant improvement in the quality of my life. I bought SAMe, too. I haven't started taking it yet. I am 60yrs old. I weigh 92lbs, 4'10" tall. I take 5-HTP 3/day-6hrs apart,on an empty stomach. I am completely dependent on my daughter-no bank account, no health insurance. I haven't been able to see a Dr since 2006-so no meds. The only thing I take is tylenol, motrin, pepcid, and OTC allergy pills. (I do take vitamins & minerals)

I haven't started taking the SAMe because I haven't been able to find out if it is safe to take both 5-HTP &SAMe. Also since both have to be taken on an empty stomach; I have to take both at the exact same time. (I have IBS- I can't have "    "           "     for more than 12 hrs/day:an hour before & after). I have hypoglycemia-so even the 2 hrs make me dizzy.

So back to my ?-can I take the SAMe, also?

THANK YOU, IN ADVANCE                         Forgot-I take 100mg. 3/day. The SAMe is 200mg-suggested dosage is 400mg 3/day.

Answer This
Answers (1)
Karen Lee Richards, Health Guide
2/23/09 10:52am

I'm so glad to hear that the 5-HTP has made such a difference for you.  I have not been able to find any potential interactions between 5-HTP and SAMe.  In case you want to check for any other possible interactions, here is a link to a site where you can check for interactions between various drugs and supplements:


I noticed that you said you take Tylenol and Motrin.  I trust you're not taking them at the same time.  Too much of either can be hard on your kidneys and liver, so I certainly wouldn't recommend taking them together. 


I hope the SAMe works well for you.

Answer This

We hope you find this general health information helpful. Please note however, that this Q&A is meant to support not replace the professional medical advice you receive from your doctor. No information in the Answers above is intended to diagnose or treat any condition. The views expressed in the Answers above belong to the individuals who posted them and do not necessarily reflect the views of Remedy Health Media. Remedy Health Media does not review or edit content posted by our community members, but reserves the right to remove any material it deems inappropriate.

By janeles50, Community Member— Last Modified: 03/12/14, First Published: 02/21/09