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Just found this site, I was taking 150mg Zytram, same family asTridural(Tramadol)increased to 300mg, and in 14 days I was in overdose mode. Dizziness, nausea, cold sweats, flushes. Stopped immediately and called Dr.He said maybe my metabolism was not fast enough to use up the dose fast enough. I went back to 150mg. then up to 200mg. This time it tok almost 4 weeks to od. oops stopped that too. Now I am to start Tridural @ 100mg to begin... I can't say what will or won't work for others, but I have to work, and have suffered many setbacks due to pain. I have epidural steroid injections every 3-4 months and blockers about 1 month intervals. I have an inoperable spinal cyst/ DDD/Osteoarthitis and I guess it's good to feel pain at least I am alive...LOL (spinal Stenosis) All this rant is for is to say DO WHAT YOU HAVE TO, to get by I am 55 and when I find the one who said these are the golden years, LOOK OUT! Carol