Definition Acute tubular necrosis is a kidney disorder involving damage to the tubule cells of the kidneys, resulting in acute kidney failure . Alternative Names Necrosis - renal tubular; ATN; Necrosis - acute tubular Causes, incidence, and risk factors Acute tubular necrosis (ATN) is caused by lack of oxygen to the kidney tissues (ischemia of the kidneys). The internal structures of the kidney, particularly the tissues of the kidney tubule, become damaged or destroyed. ATN is one of the most common structural changes that can lead to acute renal failure. ATN is one of the most common causes of kidney failure in hospitalized patients. Risks for acute tubular necrosis include: Blood transfusion reaction Injury or trauma that damages the muscles Recent major surgery Septic shock or other forms of shock Severe low blood pressure (hypotension) that lasts longer than 30 minutes Liver disease and kidney damage caused by diabetes ( diabetic nephropathy ) may make a person more susceptible to the condition. A...
Parents and doctors beware! Antibiotic use during the first year of life probably does cause asthma!
There is enough research now that we can definitely say probably. General thinking for years has been that if a child has an infection it should be treated with antibiotics. Yet newer evidence is leaning in the direction that while antibiotics cure an acute infection, it may cause asthma later on.
The most recent study was completed by Yale University researchers , and they interviewed women during pregnancy and when the child was 6-years-old. Of the 1,401 studied:
40 percent of infants given just one dose of antibiotics developed childhood asthma and allergies.
70 percent of infants given two rounds of antibiotics developed asthma
These are pretty significant statistics, and they correlate well with past studies like this one completed in 2007 at the University of Manitoba and McGill University in Montreal.
We already know that overuse of antibiotics can instigate growth of bacteria that are resistant to conventional antibiotic treatments. In fact, the nosocomial infection rate in hospitals that contributes to hospital-acquired infections is partially due to an environment that routinely uses antibiotics. So it should come as no surprise that growing antibiotic use might be suspect in other conditions.
Martin Blaser M.D., head of the Department of Internal Medicine at New York University's Langone Medical Center, recently wrote a commentary in Nature suggesting that overuse of antibiotics may be helping to fuel conditions like diabetes, inflammatory bowel disease, allergies, asthma and obesity. He notes in the commentary that these conditions have nearly doubled in many populations over the past several decades. Though experts certainly identify a myriad of contributing causes, he now adds the "killing of healthy bacteria or flora" as an additional theoretical contributor to the p...
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