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Yes opiate resistance does occur (unfortunately). Check out the below link for a paper on opiate resistance in AIDS patients.  This physician reccomends continuing to use opiates but boosting their effectiveness with other agents. He does not believe that long-term use of opiates causes tolerance. The problem may very well be genetic; researchers are beginning to disentangle genetic differences in fibromyalgia patients, for instance, that cause some of them to respond to one type of pain medication better than another.   http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1275976   You really need to find a really sharp specialist to address your pain. Some hospitals have special pain management centers.   Check out this article that suggests that opioid resistance is common in fibromyalgia patients. The presence of an injury does not mean you might not have FM as well which is characterized by widespread pain. FM is treated differently than other types of pain.  You might want to check out the FM section of this website.   http://www.medpagetoday.com/Geriatrics/PainManagement/tb/6811 http://www.healthcentral.com/chronic-pain/fibromyalgia.html     This is going to take some research. Good luck!