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Yes and No. Ultram (tramadol hydrocloride), is generally prescribed in 50mg tablets for moderate to severe pain, and for a relatively short period of time, due to the possiblity of abuse. Upon ingestion, the medication generally takes 30 min to an hour to begin working, and can be felt up to four hours after being taken. Ultram ER is different, it is prescribed in 100,200 or 300mg tablets and is obviously an Extended Release medication. It is generally suggested that one tablet every 24 hours is sufficient. I myself have had great success with this, and the ER version is not prone to abuse, due to the fact that it is so slowly released into the system. PS- unlike Ultram 50mg which has a generic Tramadol 50mg, Ultram ER is name brand only, and is expensive, with a quantity of 30 pills, costing up to $85, without a co-pay. So make the best choice for yourself. Good luck.