What's the best pain killer for sciatica? I've been on percocet then had to increase to encocet, but still have pain even with that. I'm taking naproxen for the inflammation, which basically does nothing to kill the pain. Can anyone suggest a drug that really works for this condition. I'm only 45 yrs. old, but feel like I'm about 90 suddenly. Every step I take makes my wince in pain. It's really getting me down and I'm starting to not be able to sleep. When I wake up I don't even want to get out of bed, because as soon as I put weight on my right leg I want to scream out in pain.