Generic Name: OXYCODONE/ACETAMINOPHEN - ORAL Pronounced: (OX-i-KOE-done/a-SEET-a-MIN-oh-fen) Oxycodone-Acetaminophen Oral Precautions
See also Warning section.
Before taking this medication, tell your doctor or
pharmacist if you are allergic to it; or to other narcotics (such as morphine,
codeine); or if you have any other allergies. This product may contain inactive
ingredients, which can cause allergic reactions or other problems. Talk to your
pharmacist for more details.
Before using this medication, tell your doctor or
pharmacist your medical history, especially of:
brain disorders (such as head injury, tumor,
breathing problems (such as asthma, sleep apnea, chronic
obstructive pulmonary disease-COPD)
mental/mood disorders (such as confusion,
personal or family history of regular use/abuse of
stomach/intestinal problems (such as blockage...
It's not unusual for people living with chronic pain to also be dealing with some depression and/or anxiety . But if you're taking an opioid like oxycodone for the pain and also taking an herbal supplement containing St. John's Wort, you may unknowingly be reducing the effectiveness of your pain medication. A small study in Finland found that when St. John's Wort and oxycodone were taken together, the plasma concentration of oxycodone decreased by 50 percent and its half-life (the time it takes for half the drug to be elimitated from the body) was shortened by 27 percent. The reason for the significant decrease in oxycodone's effectiveness may lie in the fact that St. John’s wort is a well-known to induce CYP450 liver enzymes, which play an important role in the metabolism of many opioids. Although oxycodone was the only opioid tested, it would be logical to think that other opioids which are metabolized through the CYP450 pathways might be similarly...
Some chronic pain patients, particularly in Florida, are finding it difficult to fill their oxycodone prescriptions at their local pharmacies. Pharmacists are telling them they don't have any oxycodone. But is that true? Maybe, maybe not.
Technically, according to the DEA, there is no shortage of oxycodone. Pharmaceutical companies are producing it at normal levels. What is in short supply are pharmacists who are willing and able to fill your prescription.
Here's the Story...
Florida has had a huge problem with unscrupulous doctors prescribing and often also dispensing large quantities of opioids, primarily oxycodone, from storefront operations commonly called “pill mills.” According to a 2011 NPR report, doctors in Florida were prescribing 10 times more oxycodone than all the other U.S. states combined.
In an effort to curb this oxy epidemic, the DEA began cracking down not only on Florida doctors, but also on pharmacies and wholesale drug dis...
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