What are the health risks of taking Hydrocodone/APAP 5MG500MG tabs over a long period of time?
I'm not aware of any studies on this - in fact long term studies of drugs are relatively rare. One might assume, then, that the long term risks of this drug probably mirror the short term ones - they are liver damage from the acetaminophen and addiction to the hydrocodone.
You can mitigate the possibility of liver damage by taking care of your liver by drinking only in light amounts, by not smoking, by having a good diet and by not taking acetaminophen in other forms, like over the counter cold medications.
Here are some links on pain medication that you might find helpful as you're learning about this:
Let’s Talk Pain Meds
What You Didn’t Know About Pain Meds
Vicodin Use - Overview