There has been a lot of news lately about medication overuse headaches (MOH) that may be linked to those of us who have chronic headaches each month. Do you think taking a 50mg tablet of Tramadol daily (for fibromyalgia) could be enough to cause MOH? Peggy.
Some patients can take tramadol daily without getting into a medication overuse headache. For others, that 50mg a day could cause MOH. If the tramadol IS causing you MOH, it should be relieved when you take the tramadol.
This is a rock-and-a-hard-place problem for people who have both headache and pain issues. Sadly, there's no good solution for it.
Good luck, John Claude Krusz and Teri Robert
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Like most of you, I take aspirin daily, 162.5mg (it used to be 325 until my stomach rebelled). Most cardiologists recommend aspirin for heart disease sufferers.
Aspirin works by interfering with the generation of thromboxane A2 (TXA2) which is needed for platelet aggregation (clotting). The COX-1 enzyme acts on arachidonic acid (AA) to produce endoperoxides that in turn produce TXA2. Aspirin interferes with the generation of TXA2 by irreversably acetylating the platelet COX-1 enzyme thereby blocking its access to AA. Because platelets are anucleate , they cannot generate additional COX-1. In the absence of TXA2, platelet aggregation does not occur. Got all that?! Most practitioners prescribe anywhere from 81mg to 325mg for heart patients. Studies such as CURE suggest 81mg is optimal. The ISIS-2 study puts the dose at 162mg (for recent heart attack sufferers) and, frankly, since aspirin is so cheap, many simply make the leap to "more must be better." Ahh, but there are downsi...
Allergy to sulfa-containing medications is very common; these are typically antibiotics. However, not all antibiotics are pills. Doctors will sometimes prescribe antibiotic eye drops or ointments for ‘pink eye’. Several eye drop preparations contain sulfa antibiotics, and it may not occur to the patient to answer that they have any drug allergies when they are getting an eye drop prescription.
For more information on the Allergen of the Month feature, see the overview , and check out the previous post on soaps and detergents.
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