FROM OUR EXPERTS
Voluntary recalls were issued for specific lots of two opioid pain relievers and one medication for tension headaches. The affected drugs include:
Endocet (oxycodone/acetaminophen), 10/325 mg
Hydrocodone/acetaminophen, 7.5/500 mg
Butalbital/acetaminophen/caffeine, 50/325/40 mg
Endocet (oxycodone/acetaminophen)Endo Pharmaceuticals issued the nationwide Endocet recall because a bottle from each of two lots was found to contain some 10/650 mg tablets, which is twice the dosage of acetaminophen on the label. Because of this, consumers may take more than the intended acetaminophen dose. Possible Dangers: Unintentional administration of tablets with increased acetaminophen content may result in liver toxicity, especially in patients on other acetaminophen containing medications, patients with liver dysfunction, or people who consume more than 3 alcoholic beverages a day. Lots: The two lots affected are Lot # 402415NV and Lot # 402426NV. They were distri...
Generic Name: IBUPROFEN/OXYCODONE 400 MG/5 MG - ORALPronounced: (eye-byou-PRO-fen/ox-ee-KOH-doan)Ibuprofen-Oxycodone Oral Precautions
Before taking this medication, tell your doctor or
pharmacist if you are allergic to oxycodone or ibuprofen; or to other narcotic
pain relievers (such as codeine, hydrocodone); or to aspirin or other NSAIDs
(such as naproxen, celecoxib); or if you have any other allergies. This product
may contain inactive ingredients, which can cause allergic reactions or other
problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or
pharmacist your medical history, especially of:
intestinal/bowel disorders (such as paralytic ileus,
infectious diarrhea, colitis, blockage)
recent heart bypass surgery (CABG)
bleeding/blood-clotting disorders (such as hemophilia,
vitamin K deficiency, low platelet count)
It's not unusual for people living with chronic pain to also be dealing with some depression and/or anxiety. But if you're taking an opioid like oxycodone for the pain and also taking an herbal supplement containing St. John's Wort, you may unknowingly be reducing the effectiveness of your pain medication. A small study in Finland found that when St. John's Wort and oxycodone were taken together, the plasma concentration of oxycodone decreased by 50 percent and its half-life (the time it takes for half the drug to be elimitated from the body) was shortened by 27 percent. The reason for the significant decrease in oxycodone's effectiveness may lie in the fact that St. John’s wort is a well-known to induce CYP450 liver enzymes, which play an important role in the metabolism of many opioids. Although oxycodone was the only opioid tested, it would be logical to think that other opioids which are metabolized through the CYP450 pathways might be similarly...
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