Wednesday, October 22, 2014

Wednesday, November 19, 2008 Kim Patterson, Community Member, asks

Q: What's the difference between hydrocodone and oxycodone?

What is the difference between hydrocodone/apap 5/500 and oxycodone 5 mg?

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Answers (2)
Cort, Health Guide
11/20/08 7:01pm

Oxycodone and hydrocodone are slightly different kinds of narcotics. Oxycodone is derived from thebaine while hydrocodone is derived from thebaine and codeine.

The 500 refers to the amount of acetaminophen in them (500 mgs) - which enhances the effect of the narcotic. With regards to strength they are both probably quite equal (providing both contain the same or similar amount of acetaminophen).

Here are some other links on pain meds that you might find useful:

Let’s Talk Pain Meds

What You Didn’t Know About Pain Meds


Krystal Selvidge, Community Member
12/ 2/10 12:04pm

For me Oxycodone helps my severe chronic pain much better than Norco which is hydrocodone 10/325. Also I do not develop a tolerance as fast to the oxycodone as I do hydrocodone.

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By Kim Patterson, Community Member— Last Modified: 09/10/14, First Published: 11/19/08