FROM OUR EXPERTS
Lisa Nelson RD #5: Should individuals with low HDL levels receive treatment even if all other levels are normal?
Dr. Shelby-Lane: According to ScienceDaily (May 29, 2005) - High circulating levels of the "good cholesterol" HDL are associated with decreased risk of cardiovascular disease . HDL helps the liver excrete extra cholesterol by binding to a receptor in the liver called scavenger receptor-BI (SR-BI). However, the signaling events between HDL and SR-BI that afforded heart healthy benefits were not known.
In a study appearing online on March 24, 2005, in advance of the April 1, 2005 print edition of the Journal of Clinical Investigation, Philip Shaul and colleagues from the University of Texas Southwestern Medical Center examine the following pathway:
The authors show that HDL activates an enzyme called eNOS and sets off a cellular signal that depends on cholesterol efflux and two intact domains of SR-BI -- the transmembrane domain and its cytoplasmic tail. These re...
Definition Hemoglobin electrophoresis is a test that measures the different types of the oxygen-carrying protein ( hemoglobin ) in the blood. Alternative Names Hb electrophoresis; Hgb electrophoresis; Electrophoresis - hemoglobin How the test is performed Blood is typically drawn from a vein, usually from the inside of the elbow or the back of the hand. The site is cleaned with germ-killing medicine (antiseptic). The health care provider wraps an elastic band around the upper arm to apply pressure to the area and make the vein swell with blood. Next, the health care provider gently inserts a needle into the vein. The blood collects into an airtight vial or tube attached to the needle. The elastic band is removed from your arm. Once the blood has been collected, the needle is removed, and the puncture site is covered to stop any bleeding. In infants or young children, a sharp tool called a lancet may be used to puncture the skin and make it bleed. The blood collects into a small glass tube calle...
Definition Hemoglobin C disease is a blood disorder passed down through families. It leads to a type of anemia, which occurs when red blood cells break down earlier than normal. Alternative Names Clinical hemoglobin C Causes, incidence, and risk factors Hemoglobin C is an abnormal type of hemoglobin, the protein in red blood cells that carries oxygen. It is a type of hemoglobinopathy . The disease is caused by problem with a gene called beta globin. The disease most often occurs in African Americans. You are more likely to have hemoglobin C disease if someone in your family has had it.
You should know
Answers to your question are meant to provide general health information but should not replace medical advice you receive from a doctor. No answers should be viewed as a diagnosis or recommended treatment for a condition. Content posted by community members does not necessarily reflect the views of Remedy Health Media, which also reserves the right to remove material deemed inappropriate.