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Ok... I have had P.N. (pn) for about 9 years now. I started with Vicodin for a few years and am now taking 90 mgs of Morphine Sulfate a day. Once in a while I'll take an extra 30, just for good measure. I also have another disease called Ataxia. This causes muscle weakness in the legs and with the both of them, I'm in  a wheel chair. The Morphine helps VERY LITTLE and I'm here on the web looking into amputation of my right foot and my left toes... I haven't found any sites yet.  Good luck to you. Try the Morphine. (I was also on Methadone...The anti depresants made me insane!)