A new study, presented at the 29th Annual Scientific Meeting of the American Pain Society in Baltimore earlier this month, gave doctors one more treatment option to consider for fibromyalgia patients . The study found that FM patients who did not have particularly good results from taking Lyrica alone experienced significantly reduced pain and greater overall improvement when taking Savella in addition to the Lyrica. Since Lyrica is effective for only about one third of FM patients, and since Lyrica and Savella have different mechanisms of action, the researchers wanted to see what happened when they were combined. Study Methods and Results In this study 173 patients were given just Lyrica and 179 were given Lyrica plus Savella for 11 weeks. The dosages used were 150 or 225 mg of Lyrica twice a day and 50 mg of Savella twice a day. By week 11, the pain scores of the Lyrica group dropped four points as measured by the Visual Analog Scale, while the pain scores of t...
Our readers ask some great questions about Migraine disease and other headache disorders here on HealthCentral's Migraine community. Nancy and I both answer questions in our community question and answer section . Dr. Krusz and I answer other questions in our Ask the Clinician column .
Some of the questions apply to many of our readers, and are great topics for discussion. So, every week, I bring you our Question of the Week. I hope you'll take a few minutes to look at these questions and the answers, then join us in discussion. One of the best things about online communities is the opportunity to share information and experiences.
This week's Question of the Week:
I have been on everything for Migraines and now my doctor want to put me on lyrica...?
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As of this writing, three medications have been approved by the FDA for the treatment of fibromyalgia: Lyrica (pregabalin), Cymbalta (duloxetine) and Savella (milnacipran). Since all three are relatively new drugs, information on how well they work and their side effects is still being gathered. Because every patient's symptoms and body chemistry are different, it is often a matter of trial and error to find the best medication for a particular patient with a particular illness. However, a recent German study , which was the first to compare the pros and cons of the three drugs head-to-head, may help doctors choose which medication has the best chance of success for any given patient. Study Design The study authors searched MEDLINE, SCOPUS, Cochrane Central Register of Controlled Trials, and sought unpublished data from the databases of FDA, US National Institutes for Health, and Industry through May 2009 for randomized controlled trials. They found 17...
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