• mary mary
    November 05, 2010
    can you take Spironolactone, Levothyroxine
    mary mary
    November 05, 2010

    i've been taking spironolactone to help suppress the adrenal gland and to help control my blood pressure. Now I recently was put on Levothyroxine for a thryoid issue. My dosage started at 25mcg, it's now at 50 mcg. Since i've started the 50 mcg im noticing my ankles are swollen, and i feel bloated all over. is this normal? is one medication canceling out the other?



  • Cort
    Health Guide
    November 05, 2010
    Health Guide
    November 05, 2010

    According to a drug interactions checker these two drugs should not interact with each other (but that is not set in stone) and fluid retention is not a common side effect for Levothyroxine. I would check with your doctor to see if there's some  reason the thyroid medication is interferring with your other medication. Interestingly, low thyroid can cause fluid retention as well. One website suggested what you're experiencing could be a temporary situation as your body adjusts to the drug. It's a pretty complex situation - one that your doctor, hopefully, can help you with.


You should know Answers to your question are meant to provide general health information but should not replace medical advice you receive from a doctor. No answers should be viewed as a diagnosis or recommended treatment for a condition. Content posted by community members does not necessarily reflect the views of Remedy Health Media, which also reserves the right to remove material deemed inappropriate.

We're sorry. The page you have requested could not be found.

If you've arrived here by typing a URL into your browser's address area, please check to make sure the spelling, capitalization, and punctuation is correct.

Or, please use the search box above to search our site for the information you were seeking.