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This is really a question for your pharmacist. The list of drugs Lyrica interacts with is a long one. http://www.drugs.com/drug-interactions/lyrica_d05508.html Lyrica does interact moderately with both Pamelor and Xanax (Xenxa?). All three are central nervous system depressants. The question would be if all three could interact together to depress your nervous system functioning too much. http://www.drugs.com/drug-interactions/lyrica_d05508_pamelor_d00144.html You really should talk to your pharmacist about this. Good luck!

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