It's not unusual for people living with chronic pain to also be dealing with some depression and/or anxiety . But if you're taking an opioid like oxycodone for the pain and also taking an herbal supplement containing St. John's Wort, you may unknowingly be reducing the effectiveness of your pain medication. A small study in Finland found that when St. John's Wort and oxycodone were taken together, the plasma concentration of oxycodone decreased by 50 percent and its half-life (the time it takes for half the drug to be elimitated from the body) was shortened by 27 percent. The reason for the significant decrease in oxycodone's effectiveness may lie in the fact that St. John’s wort is a well-known to induce CYP450 liver enzymes, which play an important role in the metabolism of many opioids. Although oxycodone was the only opioid tested, it would be logical to think that other opioids which are metabolized through the CYP450 pathways might be similarly...
Generic Name: OXYCODONE/ACETAMINOPHEN - ORAL Pronounced: (OX-i-KOE-done/a-SEET-a-MIN-oh-fen) Oxycodone-Acetaminophen Oral Interactions
See also Warning section.
The effects of some drugs can change if you take other
drugs or herbal products at the same time. This can increase your risk for
serious side effects or may cause your medications not to work correctly. These
drug interactions are possible, but do not always occur. Your doctor or
pharmacist can often prevent or manage interactions by changing how you use
your medications or by close monitoring.
To help your doctor or pharmacist give you the best care,
be sure to tell your doctor or pharmacist about all the products you use
(including prescription drugs, nonprescription drugs, and herbal products)
before starting treatment with this product. While using this product, do not
start, stop, or change the dosage of any other medicines you are using without
your doctor's approval.
Generic Name: OXYCODONE CONCENTRATE SOLUTION - ORAL Pronounced: (OX-i-KOE-done) Oxycodone Oral Uses
This medication is used to help relieve moderate to severe
pain. Oxycodone belongs to a class of drugs known as narcotic (opiate)
analgesics. It works in the brain to change how your body feels and responds to
How To Use Oxycodone Oral
Take this medication by mouth as directed by your doctor.
You may take this drug with or without food. If you have nausea, it may help to
take this drug with food. Ask your doctor or pharmacist about other ways to
decrease nausea (such as lying down for 1 to 2 hours with as little head
movement as possible).
Use the provided medicine dropper to carefully measure the
dose. Do not use a household spoon because you may not get the correct dose. Do
not confuse the dose in milligrams (mg) with the dose in milliliters (mL). You
may mix the dose with a small amount of juice, water, applesauce or pudding.
You should knowAnswers to your question are meant to provide general health information but should not replace medical advice you receive from a doctor. No answers should be viewed as a diagnosis or recommended treatment for a condition. Content posted by community members does not necessarily reflect the views of Remedy Health Media, which also reserves the right to remove material deemed inappropriate.