There’s not a one-size-fits-all treatment protocol for ME/CFS. Each patient has a unique combination of symptoms and may respond differently to various treatments. The most effective treatment programs usually involve a multi-disciplined approach, incorporating prescription medications, alternative therapies and lifestyle changes.

Prescription Medications

Any medications prescribed in the treatment of chronic fatigue syndrome / myalgic encephalopathy must be prescribed off-label, because no drugs have yet received FDA approval to treat ME/CFS. Therefore, doctors will generally prescribe medication to treat specific symptoms the patient is experiencing. Since people with ME/CFS often have a heightened sensitivity to drugs, prescribing medications can present quite a challenge. It’s usually best to start with low doses of any medication, gradually increasing the dosage as necessary. Types of medications sometimes used to treat chronic fatigue syndrome symptoms include:

• Anticonvulsants
• Antidepressants
• Antifungals
• Antihistamines
• Anti-inflammatories
• Antivirals
• Central nervous system depressants
• Corticosteroids
• Expectorants
• Immunoglobulins

Alternative Therapies

A variety of alternative therapies have been effective in helping some ME/CFS patients manage their symptoms. Some of these alternative therapies include:

• Acupuncture
• Aquatic therapy (i.e., water exercise, watsu)
• Chiropractic
• Massage therapy
• Myofascial release therapy
• Nutritional supplementation
• Reiki
• Tai chi
• Therapeutic touch
• Yoga

Lifestyle Changes

Lifestyle adaptations are key to the effective management of chronic fatigue syndrome symptoms. Making positive lifestyle changes lays a good foundation upon which other treatment plans can be built. Recommended lifestyle changes include:

• Getting more rest. (If possible, however, avoid complete bed rest, which will lead to deconditioned muscles and increased fatigue.)
• Following a regular, manageable daily routine.
• Reducing physical and emotional stress.
• Improving nutrition. (Avoid alcohol, caffeine, sugar and food additives. Many ME/CFS patients have found eating more organic foods to be very effective.) 
• Getting mild to moderate exercise regularly, but only with doctor’s approval. (for example, gentle stretching, simple water exercise)

Sources:

About CFIDS. The CFIDS Association of America, Inc., 2004

Chronic Fatigue Syndrome. MayoClinic.com, 2005