Scientists have found that non-steroidal anti-inflammatory drugs such as ibuprofen and aspirin may increase users' risk of atrial fibrillation (AF), a type of heart flutter associated with heart failure and strokes. The researchers found the greatest AF risk among new users of these pain medications, with a 70 percent increased risk in those taking COX-2 inhibitor NSAIDs (such as the drug Celebrex) and a 40 percent increased risk from other types of NSAIDs.
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