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The following is a copy of a letter sent to healthcare professionals following an FDA MedWatch warning about decreased sweating as a potentially serious side effect of Topamax: Ortho-McNeil Pharmaceutical, Inc. 1000 Route 202, PO Box 300 Raritan, NJ 08869-0602 908-218-6000 Telephone IMPORTANT DRUG WARNING Dear Healthcare Professional: The prescribing information for TOPAMAX® (topiramate/topiramate capsules) Tablets/Sprinkle Capsules has been revised to provide updated information about oligohidrosis (decreased sweating) and hyperthermia, which have been reported in topiramate-treated patients. Oligohidrosis and hyperthermia may have potentially serious sequelae, which may be preventable by prompt recognition of symptoms and appropriate treatment. This updated information is based on clinical trial and postmarketing experience in more than 2 million patients worldwide. Reports have primarily involved children. Most cases have occurred in association with exp...
Definition An abnormal lack of sweat in response to heat may be harmful, because sweating allows heat to be released from the body. The medical term for absent sweating is anhidrosis. Alternative Names Decreased sweating; Anhidrosis Considerations Anhidrosis sometimes goes unrecognized until a substantial amount of heat or exertion fails to cause sweating. Overall lack of sweating can be life threatening because the body will overheat. If the lack of sweating happens in a small area only, it is usually not as dangerous. Common Causes Burns Certain genetic syndromes Certain nerve problems (neuropathies) Congenital disorders including as ectodermal dysplasia Dehydration Neurologic disorders such as Guillain-Barre syndrome Skin diseases that block sweat glands Trauma to sweat glands Use of certain drugs
Reader: I really think I sweat too much. Why does this happen and what can I do about it now that warmer weather has arrived?
The more important question is this: When do you think you sweat too much?
If you feel you sweat too much when it's warm outside or you've exerted yourself, then your body is simply regulating its temperature. For example, if you've been walking outside for a few hours on a day when the temperature is 90 degrees Fahrenheit and you're sporting some embarrassingly damp armpits, you're sweating because you're hot and your body needs to cool down. Go indoors and sip a cold drink until your body temperature comes down a bit.
On the other hand, if you've been indoors in an air-conditioned building all day and still find yourself sweating as though you're in a sauna, you may have a condition called "hyperhidrosis."
Hyperhidrosis is a common condition that causes intense and frequent blushing and sweating that exceeds the body's need to cool...
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