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The following is a copy of a letter sent to healthcare professionals following an FDA MedWatch warning about decreased sweating as a potentially serious side effect of Topamax: Ortho-McNeil Pharmaceutical, Inc. 1000 Route 202, PO Box 300 Raritan, NJ 08869-0602 908-218-6000 Telephone IMPORTANT DRUG WARNING Dear Healthcare Professional: The prescribing information for TOPAMAX® (topiramate/topiramate capsules) Tablets/Sprinkle Capsules has been revised to provide updated information about oligohidrosis (decreased sweating) and hyperthermia, which have been reported in topiramate-treated patients. Oligohidrosis and hyperthermia may have potentially serious sequelae, which may be preventable by prompt recognition of symptoms and appropriate treatment. This updated information is based on clinical trial and postmarketing experience in more than 2 million patients worldwide. Reports have primarily involved children. Most cases have occurred in association with exp...
Alternative Names African trypanosomiasis Symptoms General symptoms include: Anxiety Drowsiness during the day Fever Headache Insomnia at night Mood changes Sleepiness (may be uncontrollable) Sweating Swollen lymph nodes all over the body Swollen, red, painful nodule at site of fly bite Weakness Signs and tests A physical examination may show signs of inflammation of the brain and its covering, the meninges (meningoencephalitis). Tests include the following: Blood smear Cerebrospinal fluid tests Complete blood count (CBC) Lymph node aspiration Most antibody and antigen tests are not very helpful because they cannot tell the difference between current and past infection. Specific IgM levels in the cerebrospinal fluid may be helpful, however.
Being a middle-age woman can really mess with your life 24/7. Lately, I’ve been waking up around 2 a.m. and have had difficulty going back to sleep. Sometimes it’s due to night sweats, although most times it’s because I have too much on my mind and I can’t seem to find the “off” switch for my brain. I’ve been tossing and turning for up to 1-1/2 hours before I can get back to sleep.
This restlessness is especially scary when you learn that a new study has found that less than six hours of sleep at night on a regular basis may lead to premature death . A research team led by Dr. Francesco Cappuccio of the University of Warwick reviewed 16 studies that involved more than 1.3 million participants around the globe who were followed for up to 25 years. Cappuccio’s team discovered that sleeping less than six hours a night was associated with a greater risk of death in comparison with those participants who slept 6-8 hours per night. The re...
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