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Do your knees feel wobbly or are your legs giving way? If you answered yes to either one of these questions, then you might be experiencing a condition known as Arthrogenic Muscle Inhibition. That’s a fancy way to say that the muscle weakness is caused by joint arthritis, injury and pain.
As a protective mechanism, the nervous system has reflexes that shut down muscle activity in order to protect the injured body part. In the case of an injured knee, ankle or other joint, doctors have observed significant muscle deactivation in response to joint swelling, pain, and arthritis. 1
In response to knee injury, surgery or arthritis, the quadriceps muscles become very weak. Even the hamstring and buttocks muscles are weakened in order to protect the knee. In response to an ankle injury or other painful process, the lower leg muscles in the calf start to lose their power. Researchers are even able to duplicate this arthrogenic muscle response by simulating joint swelling a...
Muscle pain happens to most people. After a rigorous workout, muscles can be sore for days. That’s normal muscle pain. Abnormal muscle pain is a persistent pain that does not go away with rest. The pain is deep and often unbearable. Further investigation is needed for abnormal muscle pain.
The first investigation step is laboratory tests. Pain does not accompany all muscle diseases, but an elevated creatine phosphokinase (CPK) usually does. The CPK enzyme is found in the skeletal muscles as well as the heart and brain. Non-painful causes of an elevated CPK include muscular dystrophy, dementia and motor neuron diseases. Painful conditions associated with an elevated CPK include sickle cell disease and polymyositis . Besides pain, other symptoms might provide diagnostic clues like muscle weakness which typical in polymyositis. If anemia is present, then sickle cell disease is more likely. Both polymyositis and sickle cell disease can lead to the most severe form of muscle di...
Alternative Names Neuromusclar disorder - myasthenia gravis Treatment There is no known cure for myasthenia gravis. However, treatment may result in prolonged periods without any symptoms (remission). Lifestyle adjustments usually enables continuation of many activities. Activity should be planned to allow scheduled rest periods. An eye patch may be recommended if double vision is bothersome. Stress and excessive heat exposure should be avoided because they can worsen symptoms. Some medications, such as neostigmine or pyridostigmine, improve the communication between the nerve and the muscle. Prednisone and other medications (such as azathioprine, cyclosporine, or mycophenolate mofetil) that suppress the autoimmune response responsible for the weakness may be used if symptoms are severe and other medications don't work well enough. Plasmapheresis may reduce symptoms for 4 - 6 weeks and is often used before surgery. In this technique, the person's blood plasma (the clear part of the blood) c...
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