Generic Name: DEXTROMETHORPHAN/DECONGESTANT/ANTIHISTAMINE - ORAL

PE-Hist DM Oral Interactions

If you are taking this medication under your doctor's direction, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.

This product should not be used with the following medications because very serious (rarely fatal) interactions may occur:

• MAO inhibitors (isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, selegiline, tranylcypromine)
• sibutramine

If you are currently using any of these medications listed above, tell your doctor or pharmacist before starting this medication. Avoid taking MAO inhibitors within 2 weeks of starting or stopping this medication.

Before using this product, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially:

• antihistamines applied to the skin (such as diphenhydramine cream, ointment, spray)
• antispasmodics (e.g., atropine, belladonna alkaloids)
• beta blockers (e.g., metoprolol, atenolol)
• drugs for Parkinson's disease (e.g., anticholinergics such as benztropine, trihexyphenidyl)
• guanethidine
• certain inhaled anesthetics (e.g., halothane)
• memantine
• methyldopa
• reserpine
• scopolamine
• tricyclic antidepressants (e.g., amitriptyline, desipramine)

Tell your doctor or pharmacist if you also take drugs that cause drowsiness such as: certain antihistamines (e.g., diphenhydramine), anti-seizure drugs (e.g., carbamazepine), medicine for sleep or anxiety (e.g., alprazolam, diazepam, zolpidem), muscle relaxants, narcotic pain relievers (e.g., codeine), psychiatric medicines (e.g., chlorpromazine, risperidone, amitriptyline, trazodone).

Check the labels on all your medicines (e.g., cough-and-cold products, diet aids) because they may contain ingredients that could affect your heart rate/blood pressure or cause drowsiness. Ask your pharmacist about the safe use of those products.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

---