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Nicotine leaves the body after about 48 hours, but cotinine (a metabolite of nicotine) might remain for up to a week. It seems that if trace remains were found in a blood test after 21 days, it would be more likley a result of exposure to second-hand smoke than from your previous smoking history.
More info can be found here: http://www.drugabuse.gov/NIDA_Notes/NNVol13N3/tearoff.html
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