12/20/2013
Brain connections ma...

Scientists reverse muscle aging in mice

NEWS

Researchers at Harvard Medical School say they have found a way to reverse some aspects of the aging process, at least in mice.

Previous evidence has shown that levels of the naturally-occurring chemical NAD gradually drop in the body’s cells over time. In the new study, the researchers sought to discover the effects on aging mice of increasing the levels of the chemical. 

The researchers found that after one week of boosting the mice’s NAD levels, their muscles demonstrated signs of reversed aging, including improved mitochondrial function, muscle wastage, inflammation and insulin resistance. The effects occurred on a cellular level and were not visible on the exterior of the mouse itself. The findings, published in the journal Cell, suggest that treatments involving the chemical NAD may help reverse the detrimental effects of age on muscle function.

Researchers said that their study’s results are important in that they show that at least some aspects of the aging process are reversible. They added, however, that NAD alone can not reverse all effects of aging, such as damage to DNA. They plan to begin clinical trials with humans in 2015.

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