I have had a reappearance of symptoms of depression and anxiety in the past 6 months after being free from them for 15 years. I have been on Zoloft since my second child was born when I experienced severe and ongoing depression/anxiety. The Zoloft has always worked beautifully for me. Anyway I was surprised at the return of symptoms. My doc raised the dose of Zoloft but it just didn't seem to be working as well as usual.
Anyway after a battery of tests , hormone levels for Perimenopause, thyroid function, liver function, they found a deficiency in vitamin B12. A google on this vitamin brought up the fact that deficiencies in B12 can bring about neuropsychiatric symptoms such as depression and anxiety. So looks like some B12 injections for me and then monitoring of levels. Apparently only a small amount of B12 is actually metabolised and if you have tummy problems( reflux etc ,I have a hiatus hernia) vitamin B12 may not be absorbed.
I am also taking Omega 3 fish oils because I have read some interesting articles about O3 and depression. Anyway check you B12 intake...its important to the way we feel.


Thanks for your post, Rusty. I am slated for some bloodwork and will definitely have them check the B12 levels. Maybe that will give me some more zip - I remember my grandmother having B12 shots for energy (she had thyroid issues, too, and ultimately had her's removed). I have had my thyroid checked bi-annually and it's never been the culprit although I'm still hoping ... that would be a somewhat easy fix.
Hang in there ...that's all any of us can do.
Out of Control