I was recently on effexor xr..my bp hit the roof so my doc decreased me from 225 to 150..depression came back..he upped me to 225 again but it didn't work. He does not feel the ssri will work as lexapro did not..I was on celexa for five years ..worked great.. and went off of it. When I was put back on it ..it did not work. He wants to put me on cymbalta..any recommandations???I would rather be on zoloft..i have gad with ocd..Been suffering for one year. Any help would be appeciated. Thanks


Dear Mcfarcal,
In reading your post I just had a thought... I do not know if you asked this question on the bipolarconnect portion of this healthsite/website.
There may be others in the bipolar community who may be able to best address your questions. I share this as my own experience with Celexa is for depression only and still works extremely well for me, even after seven years or so.
I do know that with any medication, there can be what is called the "refractory reponse" which essentially means that if you are taken off a medication, if you are put back on later, it will not have the same effect. This appears to be an aspect of what your concerns are.
I just share that asking this same information on the bipolar side of this website may be advantageous in giving you the insight you are looking for regarding the reaction to medications and bipolar.
I hope this may be an option or another channel to pursue. Keep us posted, if you will, on how you are doing and if we may be useful to you.
My very best thoughts are with you,
Kimberly Tyler