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Scientists Create Brain Cells from Skin: New Hope for People with Neurological Diseases

By Merely Me Sunday, February 26, 2012

What if I were to tell you that your skin could provide the answers to the mystery of brain diseases like alzheimers, epilepsy, autism, schizophrenia, and multiple sclerosis? Some researchers are saying this may someday be a possibility. In fact, this is not just speculation at this point. In the past weeks, scientists were able to generate certain types of human brain cells by "reprogramming" skin cells in the laboratory. The implications of this are huge. Until now researchers have had to rely upon using embryonic stem cells in order to recreate brain tissue. Now they have a means to avoid the controversy and ethical concerns some have about destroying human embryos for research. The other problem posed in using stem cells is that there is always the possibility that the patient's immune system would reject the new tissue which does not come from their own body.

 

Using one's own skin cells avoids these problems associated with stem cell research and more. Unlike stem cells, your skin provides immediate availability and abundance of tissue to reprogram into functional brain matter.

 

When a friend shared a link to this news story I was very excited for personal reasons. In my family alone I am coping with multiple sclerosis, my son has autism and epilepsy, and my mother has schizophrenia. Brain diseases run in my family. To think that our skin may provide answers of how to someday prevent or even cure some of these diseases is mind blowing. The researchers responsible for this discovery are also amazed. Here is a quote from Dr. Rick Livesey, lead researcher from the Gurdon Institute and Department of Biochemistry at the University of Cambridge:

 

"This approach gives us the ability to study human brain development and disease in ways that were unimaginable even five years ago."

 

Here is what we know now about this research.


University of Cambridge scientists have been able to develop cerebral cortex cells (the brain's grey matter) from skin cells. The cerebral cortex is a highly specialized part of the brain responsible for cognitive functioning including memory, language, and even consciousness.

 

• The scientists responsible for this research believe that it will eventually be possible to replace damaged brain tissue with brain cells grown in a laboratory from a sample of the patient's own skin.

 

• Another goal of this research is to reprogram the skin cells of patients who have brain disease including such disorders as autism, schizophrenia, and alzheimer's disease to grow brain cells. Brain disease could then be studied in the laboratory to see how defects develop and how environmental factors may influence brain cell functioning. In addition, it may also be possible for scientists to determine the effectiveness of pharmacological treatments for such brain disorders.

 

• One of the potential problems which will have to be overcome in using one's own skin cells to generate brain matter is that some scientists believe that this increases the risk of activating genes which cause cancer.

2/26/12 8:12pm

Hi everyone

 

If you have already seen this post over on our skin care site I do apologize.  We are simply moving this post over to our mental health area so that we can more readily access it in the future. 

 

Thanks so much for your patience,

MM

2/26/12 8:16pm

Just wanted to also move the great comments for this post over here as well.

 

Member Jon wrote:

 

hi MM
I have nerve damage and it made my skin around the area white
i thought that maybe my other medicine caused a reaction and thats what caused it
I lost feeling in that area all at once and the hair fell out
BTW thank you for the article

Jon


Merely Me

2/22/12 4:37pm
Oh my!

When did this happen Jon? Is this nerve damage permanent?

I am glad to see you. I hope you are doing okay.

MM



Carol Bradley Bursack

2/20/12 8:32am
Merelyme, this is a wonderful post! There's a lot of hope for people with depression, MS, Alzheimer's and dare I say maybe even OCD? Thanks so much for putting us in touch with this research. I'll be linking back from HealthCentral/Alzheimers.
Carol


Merely Me

2/22/12 4:48pm
Yes indeed...I was excited to read about this new research. I immediately thought of you because of your health topic.

For our members who don't already know... Carol is our wonderful community leader and writer for Health Central's Alzheimer's site. I have learned so much about this brain disease from Carol and from all the other writers who contribute their stories and wisdom to this site. The unfortunate statistics are that one out of eight people age 65 and older (13 percent) has Alzheimer's disease. So for anyone who is currently dealing with this condition or if you have a loved one with Alzheimer's you will find the information you need as well as a ton of support by following the link above.

Thanks so much for stopping by Carol...we really appreciate it and all that you do.

2/26/12 9:09pm

Hey -- I'm ready to have my whole brain rewired...or totally replaced with a brand new model.

2/27/12 6:42pm

Awww...I think you have a great brain.  You are wonderfully creative, compassionate and smart.  It is interesting to think about...replacing brain cells though.  This could happen in our future who knows?

 

Thanks so much for your comment Donna.

 

MM

2/27/12 9:00pm

With advances in nanotechnology it has become possible to deliver treatment to a very specific area without affecting surrounding tissue.

 

I think, once an effective treatment for different diseases and conditions is devised that it will be possible to repair damaged tissues and cells, or to replace those too damaged or missing; to deliver treatment and specific drugs, nutrients, whatever is needed, to cure most diseases, or minimize as much as possible their effects. I can't even imagine what advances will be made, I just know they will, if we can survive as a species long enough.

 

 

 

 

2/28/12 2:33pm

Hi Paul!

 

Yes it is groundbreaking research indeed...paving the way for all the things you mention.  I hope that we will be alive to see some of the implications of such research.

 

Thanks so much for your comment!  I hope that you are having a great day.

 

MM

2/27/12 9:32pm

My gosh, this would be something that could conceivably change my son's life, as he has actual brain damage that probably caused his developmental disability and possibly his autism.  That would be amazing.  Thanks for making us aware of this, MM.  Like Paul said, hope it can happen while our species still exists!

2/28/12 2:35pm

I know Judy...

 

This is what I wonder too about my MS...my son's autism...my mother's schizophrenia.  What will be possible in the years to come?  I don't think we can even imagine it.

 

Thanks so much for sharing.  I hope you are having a fantastic day!

MM

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By Merely Me— Last Modified: 10/24/12, First Published: 02/26/12