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Wednesday, November 04, 2009 Linda Kay, Community Member, asks

Q: Cymbalta or Pristiq, what is the difference?

I have been on 90mg of Cymbalta for 3 yrs.and it has worked well to treat my depression , however, I have gained 35 lbs. I am an aerobic instructor and eat right, and heard that the Cymbalta can cause weight gain. Dr. changed med to Pristiq- only one day into it and I have NO energy at all and am still depressed. I know I haven't given it enough time, but is there anyone who thinks Pristiq is better than Cymbalta? Than you :)

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Answers (2)
Merely Me, Health Guide
11/ 7/09 9:47am

Hi Linda


Well it seems that a lot of docs are prescribing Prestiq lately.  Many of our members are taking this or have tried it.  The reviews are a mixed bag.  Some people say it affects their libido...others say it causes them stomach problems.  Here is our Member Medication Review on Prestiq for you to look at.


The one med I have heard consistently good things about as far as no weight gain is Wellbutrin.  But everyone reacts differently to each medication.


Let us know what happens.  I hope you find the med which works the best for you.

Linda Kay, Community Member
11/ 9/09 3:42pm

Was on Pristiq for 4 days...felt like I was on speed, having panic attacks. Went back to my Cymbalta...


Merely Me, Health Guide
11/ 9/09 3:46pm

Oh my...


I am sorry you had that experience...please do share your story on our Member Medication Review...other people will want to know this information!

gram, Community Member
2/19/12 12:32am

The Pristiq made me have extremely low energy also. I now take it at night insteado f the morning...I sleep much better and am not groggy or tired the next day.

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We hope you find this general health information helpful. Please note however, that this Q&A is meant to support not replace the professional medical advice you receive from your doctor. No information in the Answers above is intended to diagnose or treat any condition. The views expressed in the Answers above belong to the individuals who posted them and do not necessarily reflect the views of Remedy Health Media. Remedy Health Media does not review or edit content posted by our community members, but reserves the right to remove any material it deems inappropriate.

By Linda Kay, Community Member— Last Modified: 02/19/12, First Published: 11/04/09