I usually take generic Wellbutrin SR, but when I picked up my prescription this time, the bottle said it was XL instead. What does this mean? The XL is double the cost of SR so I want to make sure there is a substantial difference.
I took your question to Dr. John Claude Krusz. He runs a multi-specialty practice in Dallas treating Migraine, headaches, pain, mood disorders, and sleep disorders. Here's his answer:
The XL is more expensive but doles out the medication over 8-10hrs; the XR is sort of time-release - take 5-6 hours to release. Ultimately there should not be any difference if effect.
Here are some articles you might find useful:
Anatomy of a Migraine
Common Migraine Triggers
10 Common Triggers of Migraine (Infographic)
OK. I went to the FDA site and got the labeling information for both of these. Let's see what the difference is:
Wellbutrin SR: The SR stands for Sustained Release.
Wellbutrin XL: The XL stands for Extended Release.
Well, I'm having trouble finding the difference. Tell you what -- I'm going to email a doctor who will KNOW the difference and get back to you. OK?
SR stands for sustained-release and has a time to peak serum blood level of approximately 3 hours, whereas XL stands for extended-release and has a time to peak serum blood level of approximately 5 hours. Wellbutrin is 87% primarily excreted in the urine. The SR form does not last as long in the body and usually needs a twice-daily dosing whereas the XL form stays longer in the body and only needs once-daily dosing.