• grannyelaine grannyelaine
    July 23, 2009
    What do SR and XL mean on my medications?
    grannyelaine grannyelaine
    July 23, 2009

    I usually take generic Wellbutrin SR, but when I picked up my prescription this time, the bottle said it was XL instead. What does this mean? The XL is double the cost of SR so I want to make sure there is a substantial difference.

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FROM OUR EXPERTS

  • Teri Robert
    Health Guide
    July 24, 2009
    Teri Robert
    Health Guide
    July 24, 2009

    I took your question to Dr. John Claude Krusz. He runs a multi-specialty practice in Dallas treating Migraine, headaches, pain, mood disorders, and sleep disorders. Here's his answer:

    The XL is more expensive but doles out the medication over 8-10hrs; the XR is sort of time-release - take 5-6 hours to release. Ultimately there should not be any difference if effect.

    Here are some articles you might find useful:

    Anatomy of a Migraine

     

    Common Migraine Triggers

     

    10 Common Triggers of Migraine (Infographic)


  • Teri Robert
    Health Guide
    July 23, 2009
    Teri Robert
    Health Guide
    July 23, 2009

    grannyelaine,

     

    OK. I went to the FDA site and got the labeling information for both of these. Let's see what the difference is:

     

    Wellbutrin SR: The SR stands for Sustained Release.

     

    Wellbutrin XL: The XL stands for Extended Release.

     

    Well, I'm having trouble finding the difference. Tell you what -- I'm going to email a doctor who will KNOW the difference and get back to you. OK?

     

    Thanks!
    Teri


FROM OUR COMMUNITY

  • gary4921 February 25, 2012
    gary4921
    February 25, 2012

    SR stands for sustained-release and has a time to peak serum blood level of approximately 3 hours, whereas XL stands for extended-release and has a time to peak serum blood level of approximately 5 hours. Wellbutrin is 87% primarily excreted in the urine.  The SR form does not last as long in the body and usually needs a twice-daily dosing whereas the XL form stays longer in the body and only needs once-daily dosing.

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