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Thursday, January 22, 2009 Mercury, Community Member, asks

Q: prozac and amitriptyline drug interactions

Is it okay to take Prozac and Amitriptyline together?

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Answers (3)
psychoward1, Community Member
1/23/09 4:15am

This is a major drug-drug interaction when checked at:


So I would check with your doctor and/or pharmacy about this.


Good luck,



Mercury, Community Member
1/23/09 10:15pm

Thank you Pat. I read this also but my doctor says I should be okay, but to just keep him informed of any worrisome side effects. I am really only using the Amitriptyline for sleep and the Prozac for my depression and anxiety. I told my doctor I needed something for sleep because the Prozac, although it's doing well for me, it hypes me up a bit and I was having these black bags under my eyes. I told my doc I specifically did not want a benzo because after my husband's death I was on Xanax for about 7 years and when I finally went off of it, it was so hard. I went through detox actually. Some truly strange things occurred, believe me. Undecided So anyway he added the Amitriptyline for a sleep aid. I guess I'll just wait and see what happens . . . . . . . Thanks again Pat.

briiiie., Community Member
11/19/09 8:09am

as long as your on a lower amount of it then you should be ohkay. im am currently on the same thing for my anxiety disorder. so you should be ohkay, :]

rob uk, Community Member
5/14/11 12:23pm

is it ok to stay on amytriptalyne for long periods? i know its ok for prozac?

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By Mercury, Community Member— Last Modified: 03/13/14, First Published: 01/22/09