• Inquisitive29 Inquisitive29
    February 27, 2009
    Does going off Wellbutrin cause weight gain?
    Inquisitive29 Inquisitive29
    February 27, 2009

    I have been taking Wellbutrin for almost two years, and I have recently been weaned off the drug. In that time, I've gained 10 lbs, despite my working out every day. I have never gained weight at this rapid pace before no matter what I have been eating. Is this a normal side effect of going off the drug? 

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FROM OUR EXPERTS

  • Merely Me
    Health Guide
    February 27, 2009
    Merely Me
    Health Guide
    February 27, 2009

    I know that a lot of people either maintain their weight or else lose weight while taking Wellbutrin, though after doing some research, it seems that others have also experienced weight gain after they've stopped taking it.  For reference, you might have a look at a discussion here.

     

    I would strongly suggest that you talk to your doctor about your weight gain and what can be done. You could also be experiencing some kind of underlying medical issue that's contributing to your weight gain, and it's best to have your doctor check you out.

     

    Here are some articles you might find useful in the meantime:

     

    Five Tips to Health at Any Size

     

    Nutrition Label Reading 101 Part 1 – The HealthGal Way

     

    Nutrition Label Reading 101 Part 2 – Sodium, Fats, and Serving Size

     

    • mary
      May 21, 2012
      mary
      May 21, 2012

       Hi, I've been taking welbutrin for 6 months, decided to wein myself off of it, and it seems that i've gained about 5-8lbs back?! plus I'm on a med for hypothyrodizm (sorry, cant spell). my eating habits and exercise have not changed. I have a follow up in two weeks with my doctor. In the mean time i decided to start taking the welbutrin again.. guess we'll see what happens.. very frustrating!

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FROM OUR COMMUNITY

  • psychoward1 February 27, 2009
    psychoward1
    February 27, 2009

    Weight gain when stopping wellbutrin is a possibility. More likely something to do with the cymbalta. I put on a lot of weight around the time I was on cymbalta. There is a site that has good info about getting off and staying off antidepressants. I believe they also have a platform for weightloss.

     

    www.theroadback.org

     

    Good luck,

     

    Pat

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  • eulaliabon November 05, 2013
    eulaliabon
    November 05, 2013

    Yes, while the anoretic (appetite suppressing) effect is often discussed, increased appetite upon cessation is also common side effect. Drug companies don't like to mention the effects of discountinuation.

    Appetite is moderated by a complex network of hormones that converge on dopamine-producing neurons in the brain. Bupropion is a dopamine reuptake inhibitor and therefore elevates the amount of extracellular dopamine in the brain (aka dopamine that is available for use). People who have increased levels of dopamine transport need less food before feeling satisfied than those with less dopamine. Therefore, many people experience weight loss due to appetite suppression when they begin bupropion. Some who experience weight loss will then gain the weight back upon discontiunation, some will not gain the weight back after losing it, and some will not initally lose weight but gain after cessation. 

    The latter effect (no weight loss, then weight gain) happened to me as well as a friend of mine. We were both thin females in our early 20's. As for myself, I was already not eating very much because I was prettty depressed and wasn't receiving the rewarding feelings from food and therefore was only eating the bare minimum to keep me going when I began wellbutrin. I think I had such little dopamine that eating until I felt release was unachievable. After being on wellbutrin for a while my dopamine system ramped up and I felt increased rewarding feelings after eating and well as in general. I gained 10 lbs and got to a much healthier weight.Then after doing quite a bit of emotional healing I weaned off of wellbutrin and experienced rapid weight gain, I think it was 15lbs in 1.5 months putting me 25lbs over when i began the drug.  I had never watched my weight before and it really surpised me, but I just paid attention to what I ate (I still didn't eat that well). My body slowly adjusted and I lost the additional 15lbs over the next 6 months. I hope this helps someone, I know the original question was asked long ago.

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