• Inquisitive29 Inquisitive29
    February 27, 2009
    Does going off Wellbutrin cause weight gain?
    Inquisitive29 Inquisitive29
    February 27, 2009

    I have been taking Wellbutrin for almost two years, and I have recently been weaned off the drug. In that time, I've gained 10 lbs, despite my working out every day. I have never gained weight at this rapid pace before no matter what I have been eating. Is this a normal side effect of going off the drug? 




  • eulaliabon November 06, 2013
    November 06, 2013

    Yes, while the anoretic (appetite suppressing) effect is often discussed, increased appetite upon cessation is also common side effect. Drug companies don't like to mention the effects of discountinuation.

    Appetite is moderated by a complex network of hormones that converge on dopamine-producing neurons in the brain. Bupropion is a dopamine reuptake inhibitor and therefore elevates the amount of extracellular dopamine in the brain (aka dopamine that is available for use). People who have increased levels of dopamine transport need less food before feeling satisfied than those with less dopamine. Therefore, many people experience weight loss due to appetite suppression when they begin bupropion. Some who experience weight loss will then gain the weight back upon discontiunation, some will not gain the weight back after losing it, and some will not initally lose weight but gain after cessation. 

    The latter effect (no weight loss, then weight gain) happened to me as well as a friend of mine. We were both thin females in our early 20's. As for myself, I was already not eating very much because I was prettty depressed and wasn't receiving the rewarding feelings from food and therefore was only eating the bare minimum to keep me going when I began wellbutrin. I think I had such little dopamine that eating until I felt release was unachievable. After being on wellbutrin for a while my dopamine system ramped up and I felt increased rewarding feelings after eating and well as in general. I gained 10 lbs and got to a much healthier weight.Then after doing quite a bit of emotional healing I weaned off of wellbutrin and experienced rapid weight gain, I think it was 15lbs in 1.5 months putting me 25lbs over when i began the drug.  I had never watched my weight before and it really surpised me, but I just paid attention to what I ate (I still didn't eat that well). My body slowly adjusted and I lost the additional 15lbs over the next 6 months. I hope this helps someone, I know the original question was asked long ago.

  • psychoward1 February 27, 2009
    February 27, 2009

    Weight gain when stopping wellbutrin is a possibility. More likely something to do with the cymbalta. I put on a lot of weight around the time I was on cymbalta. There is a site that has good info about getting off and staying off antidepressants. I believe they also have a platform for weightloss.




    Good luck,



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