Wellbutrin had no effect on me, even though my sister was  taking it. Remeron was the worst---for me---medication. It sedated me to the point of feeling like a robot. It interfered w/my gross motor skills (stumbled, etc.), and I gained weight. So no affect and weight gain for me!   I went back to Zoloft and asked my doctor to give me something for my sleep problems But as Cindy said in her response to you earlier it's very hard to predict what will work for each individual. Zoloft has stopped working for me after 2 years and I am switching to Pristiq slowly. I just hope it works for me.   By the time you read my response, I wish that you have found the right anti-depressant for YOU, whichever one it is.