It can be for most people, but only after they've consulted with the prescribing doctor.
That's because the doctor knows what other medications you are taking which may interact with Pristiq, and any medical conditions you have, your history and your present health.
No one can assure you of it's safety over the internet for you, even if some of us have used more than that amount without a problem, others have had undesirable side effects with just 50 mg.
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