Hey Shane   This is a question I had asked my doctor too, when considering an anti-depressant.  I remember that she said the Prozac had some of the most sexual side effects.  She also told me that Zoloft was kinda in between and Wellbutrin caused the least.    I am not a doctor and I have also not had any experience with these drugs with the exception of Prozac.    Here is a really good article to read where doctors compare the sexual side effects of the various anti-depressants on the market.   And in this article entitled, APA: Bupropion and Nefazodone Cause Less Sexual Dysfunction Than Other New Generation Antidepressants  they found that:   "In the overall study population, Wellbutrin SR® (bupropion HCl) Sustained-Release was associated with the lowest rate of sexual dysfunction (25 percent) after Wellbutrin® (bupropion HCl) (22 percent), compared with an average of approximately 40 percent across the SSRIs, venlafaxine and mirtazapine."   I hope this helps some.  I am also hoping that people will chime in with their experiences with the different anti-depressants and how it affects their sexual functioning.    Thank you for your question!