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I was on two 75mg of Effexor XR for two years.  My Doctor said Effexor made migraines worse.  I came off it by decreasing it in three weeks.  I still suffered from what felt like electric shocks in my head four days afterwards.  I am now on Fluox two 20mg a day but have only been on it for three weeks so am hoping it will kick in within six weeks otherwise I have to take three tablets. Never go cold turkey with Effexor Xr.  I know how you are feeling as I tried it once.  I told my Chemist and he told me to start taking it again slowly.  Effexor seems a very difficult drug to come off. I take Imigran for migraines and they stop them straight away.  I have High Blood Pressure so have to be careful.  I take Seroquel to sleep.  If anyone knows anything about Seroquel could they let me know please.  With Effexor I took one 75mg and one 35mg per day, then one week of 75mg a day, then one week of 35mg a day to get off it.  Now I have hit rock bottom.  Disregard what I said about Effexor-XR giving you migraines I think it was another drug that does that. I would start the Effexor-XR again and come off it slowly if you wish to come off it. Good Luck Liz