• Kathy_42 Kathy_42
    May 29, 2010
    How long does Deplin take to work? Are there side effects with the treatment?
    Kathy_42 Kathy_42
    May 29, 2010

    Hello -

     

    I was recently asked to try a combination of Deplin and Methyl B-12 to treat my depression.  I am also taking Lamitol.  My folate levels were also recently tested and were found to be very low.  I have been on the Deplin and Methyl B-12 treatment for one month.  What I am hearing is that this is a miracle treatment for some; however, I have felt no relief to date.  How long does this treatment take to work?  Are there side effects associated with this treatment?  Other options recommended to me include Metanx and Cerefolin NAC as an alternative to Deplin.  Are these valid alternatives to Deplin that might work better?

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  • moonmom January 11, 2013
    moonmom
    January 11, 2013

    I am taking it by itself. I worked in one day. I dosed 7.5 at bed, and again in the morning. I have been depressed most of my life, but functional. I started suffering from chronic pain after an accident. They gave me every antidepressant ever made. I tried them all for the grueling 3-4 weeks I was told to wait...nothing. Only groggy and weird side efects. I tried specific vitamins that were suposed to help. Also, just getting by. This whole process took years. Every now and then I research what's new. I found Deplin. I got a scrip...and without any other chemical in the mix, it worked like magic, overnight. It's so weird to...just...feel...good.

    I highly recomend this!!!

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  • denise June 13, 2010
    denise
    June 13, 2010

    i found out w. myself that the deplin started workin 4 me within 10 days what dosage r u on?? there is a 7.5 mg & a 15 mg. u may need a higher dose i am not a professional b-complex has also helped me i am also taking lamictal this drug is a really good mood stabilizer 4 me this drug can be also tested w. blood work 2 c if you're on the right dosage 2. dr. may have samples of deplin there is no substitute 4 deplin cerefolin?? or anything u can get on the internet pamlab (manuf.) of this drug has a discount program contact them @ deplin.com if u have a Kmart pharm. in your state they discount this drug substantially it is expensive but i found it was very much worth it dr. & i tried very (& i mean very) many drugs before we tried this it is not the same as folic acid as some people might think good luck 2 u there is another web site under the mayo clinic that has alot of conversation about deplin denise not a dr. or a nurse

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  • denise May 31, 2010
    denise
    May 31, 2010

    im not a professional but i did start taking deplin about a month ago & 4 me it starting working between 7-10 days and what a difference you'll know when it starts working you should see a big difference in energy and so many other things!! most people get relief from their depress. see the deplin web site, also there's a blog on the health central page which is very helpful and gave me alot of hope even though it has been working 4 me!! your dr. should have manufacter info. on deplin & may be able 2 get samples 4 u 2?? read my blog (denise) on the health central web site & you'll get alot more info. im on lamictal 2 but the info. from pamlab (deplin manu.) says that lamictal interacts w. deplin haven't seen my dr. yet 2 ask him this?? hope this info. helped & good luck 2 u

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  • Donna-1 May 30, 2010
    Donna-1
    May 30, 2010

    I took the 7.5 dose of Deplin for about a year and thought I was not getting any benefit.  But since I've stopped it, about 3 months ago, I felt more depressed the first month, and now I'm feeling okay.  I stopped taking it because my insurance doesn't cover it and it was too expensive.  My pdoc still thinks it would be a good idea to take it.

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    • denise
      May 31, 2010
      denise
      May 31, 2010

      donna read what i (denise) wrote about my experience w. deplin it might help? it is expensive but i also wrote in a blog page @ health central under deplin.com about several different ways to get it cheaper & some drs. have samples don't stop if it helps i know its hard 2 pay that much 4 it (im on a limited income) but if it helps?? if u live in a state that has Kmart stores they have a disc. program that u save $15- i pay about $68- for the 15 mg. pills 4 a one month supply that's pretty good compared 2 my reg. drug store CVS that charges $100-!! don't know about the other meds. that were listed, but know that folic acid is not the same thing-just know this from my research im not a professional good luck 2 u and NEVER give up!!

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    • jacueline
      June 29, 2012
      jacueline
      June 29, 2012

      IT IS EXPENSIVE I JUST STARTED DEPLIN 15 MG. MY DR. LOOKED AROUND AND ORDERED MINE FROM DHF PHARMACUTICALS 144$ FOR 3 MONTHS.            JACKIE FROM BUFFALO

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    • denise
      July 04, 2012
      denise
      July 04, 2012

      dear jackie: try getting samples from your doctor they can get them from the rep. for the company that manufactures it, as for how long it takes to work it should be right away as it is considered a "medical food" & that's why it's not covered by our insurance, there are no side effects hope this helped you

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    • Donna-1
      March 04, 2014
      Donna-1
      March 04, 2014

      The following comes from this site: http://www.deplin.com/folate-for-depression/

       

       

      Folate (B9) is part of a healthy diet and is commonly found in green leafy vegetables, legumes, nuts, orange juice and some fruits. Folate (B9) is water-soluble, and the body requires it for cell growth and reproduction. It is essential for general health.

       

      The body must digest and process folic acid, synthetic B9, before it can be used by the body. In fact, the body goes through several steps in order to “break down” the folic acid and get the full benefit. This is a complex process which is shown, step-by-step, in the chart below. As a result of these steps, the body makes a version of the folate called L-methylfolate.

      folate for depression

      The importance of L-methylfolate is that it, unlike folic acid, can cross the blood brain barrier. It has been shown that many people have a genetic error called the MTHFR polymorphism that limits their body’s ability to reduce folic acid into L-methylfolate.

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    • Tina
      June 13, 2014
      Tina
      June 13, 2014

      Jackie,

      Do you have a phone number for DHF Pharmacuticals?

       

      Thank you.

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  • kronlage May 30, 2010
    kronlage
    May 30, 2010

    There are two doses for Deplin:  7.5mg and 15mg.  If you and your doctor feel that you have not achieved an adequate response to 7.5mg in 4-6 weeks, the 15mg dose may be a better choice.  Metanx and CerefolinNAC both contain L-methylfolate but at subtherapeutic doses for depression.

     

    I hope this helps and wish you the very best.

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  • behaviorquest March 04, 2014
    behaviorquest
    March 04, 2014

    Instead you might want to try EnLyte a more broad spectrum of L-Methyl folate and all of the vitamin B vitamins along with some EPA and DHA.  Check them out by using Google.  This may well be a real paradigm shift in our thinking of depression.

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  • Crystal June 14, 2014
    Crystal
    June 14, 2014
    I would ask your pharmacist how long it takes for you to see a difference in taking Deplin. Also ask if there are any side effects. As you probably know, Deplin is a breakdown of folic acid. I have not started mine yet. It is very expensive even with my insurance. I am looking into other cost effective ways to purchase it. READ MORE
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