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Saturday, May 29, 2010 Kathy_42, Community Member, asks

Q: How long does Deplin take to work? Are there side effects with the treatment?

Hello -

 

I was recently asked to try a combination of Deplin and Methyl B-12 to treat my depression.  I am also taking Lamitol.  My folate levels were also recently tested and were found to be very low.  I have been on the Deplin and Methyl B-12 treatment for one month.  What I am hearing is that this is a miracle treatment for some; however, I have felt no relief to date.  How long does this treatment take to work?  Are there side effects associated with this treatment?  Other options recommended to me include Metanx and Cerefolin NAC as an alternative to Deplin.  Are these valid alternatives to Deplin that might work better?

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Answers (7)
Donna-1, Community Member
5/30/10 3:17pm

I took the 7.5 dose of Deplin for about a year and thought I was not getting any benefit.  But since I've stopped it, about 3 months ago, I felt more depressed the first month, and now I'm feeling okay.  I stopped taking it because my insurance doesn't cover it and it was too expensive.  My pdoc still thinks it would be a good idea to take it.

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denise, Community Member
5/31/10 10:41pm

donna read what i (denise) wrote about my experience w. deplin it might help? it is expensive but i also wrote in a blog page @ health central under deplin.com about several different ways to get it cheaper & some drs. have samples don't stop if it helps i know its hard 2 pay that much 4 it (im on a limited income) but if it helps?? if u live in a state that has Kmart stores they have a disc. program that u save $15- i pay about $68- for the 15 mg. pills 4 a one month supply that's pretty good compared 2 my reg. drug store CVS that charges $100-!! don't know about the other meds. that were listed, but know that folic acid is not the same thing-just know this from my research im not a professional good luck 2 u and NEVER give up!!

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jacueline, Community Member
6/29/12 9:19pm

IT IS EXPENSIVE I JUST STARTED DEPLIN 15 MG. MY DR. LOOKED AROUND AND ORDERED MINE FROM DHF PHARMACUTICALS 144$ FOR 3 MONTHS.            JACKIE FROM BUFFALO

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denise, Community Member
7/ 4/12 8:21pm

dear jackie: try getting samples from your doctor they can get them from the rep. for the company that manufactures it, as for how long it takes to work it should be right away as it is considered a "medical food" & that's why it's not covered by our insurance, there are no side effects hope this helped you

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Tina, Community Member
6/13/14 8:54am

Jackie,

Do you have a phone number for DHF Pharmacuticals?

 

Thank you.

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Donna-1, Community Member
3/ 4/14 8:18pm

The following comes from this site: http://www.deplin.com/folate-for-depression/

 

 

Folate (B9) is part of a healthy diet and is commonly found in green leafy vegetables, legumes, nuts, orange juice and some fruits. Folate (B9) is water-soluble, and the body requires it for cell growth and reproduction. It is essential for general health.

 

The body must digest and process folic acid, synthetic B9, before it can be used by the body. In fact, the body goes through several steps in order to “break down” the folic acid and get the full benefit. This is a complex process which is shown, step-by-step, in the chart below. As a result of these steps, the body makes a version of the folate called L-methylfolate.

folate for depression

The importance of L-methylfolate is that it, unlike folic acid, can cross the blood brain barrier. It has been shown that many people have a genetic error called the MTHFR polymorphism that limits their body’s ability to reduce folic acid into L-methylfolate.

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kronlage, Community Member
5/30/10 2:28pm

There are two doses for Deplin:  7.5mg and 15mg.  If you and your doctor feel that you have not achieved an adequate response to 7.5mg in 4-6 weeks, the 15mg dose may be a better choice.  Metanx and CerefolinNAC both contain L-methylfolate but at subtherapeutic doses for depression.

 

I hope this helps and wish you the very best.

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denise, Community Member
5/31/10 10:28pm

im not a professional but i did start taking deplin about a month ago & 4 me it starting working between 7-10 days and what a difference you'll know when it starts working you should see a big difference in energy and so many other things!! most people get relief from their depress. see the deplin web site, also there's a blog on the health central page which is very helpful and gave me alot of hope even though it has been working 4 me!! your dr. should have manufacter info. on deplin & may be able 2 get samples 4 u 2?? read my blog (denise) on the health central web site & you'll get alot more info. im on lamictal 2 but the info. from pamlab (deplin manu.) says that lamictal interacts w. deplin haven't seen my dr. yet 2 ask him this?? hope this info. helped & good luck 2 u

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denise, Community Member
6/13/10 2:04am

i found out w. myself that the deplin started workin 4 me within 10 days what dosage r u on?? there is a 7.5 mg & a 15 mg. u may need a higher dose i am not a professional b-complex has also helped me i am also taking lamictal this drug is a really good mood stabilizer 4 me this drug can be also tested w. blood work 2 c if you're on the right dosage 2. dr. may have samples of deplin there is no substitute 4 deplin cerefolin?? or anything u can get on the internet pamlab (manuf.) of this drug has a discount program contact them @ deplin.com if u have a Kmart pharm. in your state they discount this drug substantially it is expensive but i found it was very much worth it dr. & i tried very (& i mean very) many drugs before we tried this it is not the same as folic acid as some people might think good luck 2 u there is another web site under the mayo clinic that has alot of conversation about deplin denise not a dr. or a nurse

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moonmom, Community Member
1/11/13 10:01pm

I am taking it by itself. I worked in one day. I dosed 7.5 at bed, and again in the morning. I have been depressed most of my life, but functional. I started suffering from chronic pain after an accident. They gave me every antidepressant ever made. I tried them all for the grueling 3-4 weeks I was told to wait...nothing. Only groggy and weird side efects. I tried specific vitamins that were suposed to help. Also, just getting by. This whole process took years. Every now and then I research what's new. I found Deplin. I got a scrip...and without any other chemical in the mix, it worked like magic, overnight. It's so weird to...just...feel...good.

I highly recomend this!!!

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moonmom, Community Member
1/11/13 10:03pm

Damn, if it gets even better in 10 days I'll be positively euphoric.

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behaviorquest, Community Member
3/ 4/14 3:01pm

Instead you might want to try EnLyte a more broad spectrum of L-Methyl folate and all of the vitamin B vitamins along with some EPA and DHA.  Check them out by using Google.  This may well be a real paradigm shift in our thinking of depression.

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Crystal, Community Member
6/14/14 10:14pm
I would ask your pharmacist how long it takes for you to see a difference in taking Deplin. Also ask if there are any side effects. As you probably know, Deplin is a breakdown of folic acid. I have not started mine yet. It is very expensive even with my insurance. I am looking into other cost effective ways to purchase it. Reply
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We hope you find this general health information helpful. Please note however, that this Q&A is meant to support not replace the professional medical advice you receive from your doctor. No information in the Answers above is intended to diagnose or treat any condition. The views expressed in the Answers above belong to the individuals who posted them and do not necessarily reflect the views of Remedy Health Media. Remedy Health Media does not review or edit content posted by our community members, but reserves the right to remove any material it deems inappropriate.

By Kathy_42, Community Member— Last Modified: 06/14/14, First Published: 05/29/10