I haven't heard of this, but I have had the same question about other psychotropic meds -- can they cause unwanted changes in brain function/biology/chemistry and can those unwanted and unforseen changes be reversed?  When I was taking Zyprexa and I would relapse within 2 days of going off of it, I just had to wonder if it was because my mental illness was really on the rebound or whether the medication had "guaranteed" relapse through changes to the brain that were supported by the med.  Does that make sense?  I'm not saying the Zyprexa didn't help, because it certainly did.  I was just wondering when/if I would ever be able to go without it.  Now, I have switched to Saphris and seem to be doing fine w/o the Zyprexa.  And I'm not going to go off the Saphris to find out if I can do without it.  Why would I when I am functioning so well with it?  I'm sorry you had a hellish experience with the Remeron and Lexapro combo.  What helps one person often can and does not do the same for another.