Full Question: About 18 months ago, I was first treated by a neurologist. I tried several medications for migraines and began to use Maxalt 10 mg. and also Topamax. I had a lot of problems with headaches waking me up from sleep. My doctor gave me Topamax and the headaches at nighttime completely went away. Unfortunate, I began to have pain behind my eyes and was advised to immediately quit the medication. It has now been 6 months since I stopped the Topamax and the night headaches have come back with a vengeance. Also, after almost pain-free days I am again experiencing more headaches. I hesitate to take the Maxalt because I also take Zoloft and my ob doctor has a certain concern about taking both of these medications. Do you see a problem with taking both? Also, have other new preventive medications come out in the last 6 months since I have seen my doctor? Any advice that I could pass on to my neurologist would be appreciated. I have an appointment next month. I need help now but...
Full Question: I am a 59 year old female with a history of migraine headaches. I have found great success with Imitrex Nasal spray, giving me only a stiff neck afterwards. Now I have Chronic Fatigue and am on 100mg of Zoloft and 25 mg of trazodone to sleep. My psychiatrists says I can't use Imitrex with the Zoloft because I might get serotonin syndrome. I did use it before when I was on 50 mg of Zoloft. I can quit the trazodone and find other sleep medications if I can use the 100 mg of Zoloft and the Imitrex. If not, I'm stuck with other pain killers that are a drag and don't work that well. What is your opinion on my dilemma? Thank you, Anna. Answer: Dear Anna; Serotonin syndrome is very rare, but we get this question frequently. Please see another recent answer for more information HERE . It would also be advantageous to have your psychiatrist consult with the doctor who treats your Migraines. Good luck, John Claude Krusz and Teri Robert About As...
Several new medications for the treatment of depression have been introduced over the last 20 years. What has been missing is any consistent data about the effectiveness of these "second-generation" antidepressants.
A team of researchers have now reviewed 117 controlled trials to compare second-generation antidepressants for the acute treatment of unipolar major depressive disorder in adults. The medications were reviewed for efficacy (effectiveness), patient acceptability, and cost.
Researchers reviewed 117 controlled trials of second-generation antidepressants.
These trials had a total of 25,928 participants.
The antidepressants compared were:
Medications were judged by the proportion of patien...
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