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Hi Leslie: My short answer is that Zoloft and Wellbutrin shouldn't show up on any drug test, and shouldn't be a concern if they did. Drug tests look for specific drugs that people take to self medicate, such as marijuana, cocaine (and its metabolites), opiates, alcohol and benzodiazepines. Unfortunately, Xanax is a benzodiazepine. If you have a prescription for it, you may want to tell them and show them a copy of your prescription before your drug test. If you are concerned about the test, talk with your physician about your concerns and he may help you consider alternative treatments that won't pop on these tests.   I hope this helps, Dr. Diana Walcutt   *Dr. Walcutt is a Psychologist, not a Psychiatrist. Psychiatrists prescribe medications. Psychologists study them, but most Psychologists are not authorized to prescribe meds or give you specific advice about them. Dr. Walcutt's answers are not intended to diagnose or treat any medical or mental disorder. Any information given in a post about medication is for educational purposes only, and primarily to aid you in having an informed discussion with your own Psychiatrist/Physician.